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Fixed-Mass Different Volumes Bupivacaine TAP Block After Cesarean

Ultrasound-guided Transversus Abdominis Plane Block After Cesarean Section Using Two Different Bupivacaine Volumes With a Fixed Drug Mass. A Randomized Comparative Trial.

Status
Not yet recruiting
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07616180
Enrollment
50
Registered
2026-06-01
Start date
2026-06-06
Completion date
2026-10-01
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caesarean Section, Postoperative Pain, TAP Block

Brief summary

Cesarean section is commonly associated with moderate to severe postoperative pain, which may delay mobilisation, impair breastfeeding, and affect mother-infant bonding. Although opioids, NSAIDs, and neuraxial techniques are commonly used for post-cesarean analgesia, their side effects have encouraged the use of peripheral nerve blocks such as the transversus abdominis plane block. The TAP block is a fascial plane block that provides analgesia by depositing local anaesthetic between the internal oblique and transversus abdominis muscles. Its efficacy after cesarean section has been demonstrated, particularly when long-acting intrathecal opioids are not used. However, the optimal local anaesthetic volume and dose remain unclear. Since the TAP block depends on adequate spread of local anaesthetic, larger volumes may improve analgesic coverage, but increasing the dose may raise the risk of systemic toxicity. Therefore, this study investigates whether using the same fixed mass of bupivacaine in two different volumes affects the analgesic efficacy of TAP block after cesarean section, hypothesising that the larger volume may provide better postoperative analgesia.

Interventions

DRUGBupivacaine

Ultrasound-guided bilateral transversus abdominis plane block using 150 mg plain bupivacaine after cesarean section. The same total bupivacaine dose will be administered in two different volumes: 60 mL total volume, 30 mL per side

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* full-term parturients, * aged \> 18 years * ASA physical status II * patients who are scheduled for elective CS with Pfannenstiel incisions under spinal anaesthesia.

Exclusion criteria

* Parturients with contraindications to spinal anaesthesia, * Having a scar or infection at the site of the block * BMI \> 35 Kg/m2, * on chronic use of pain medications, * Refusing to participate.

Design outcomes

Primary

MeasureTime frame
total postoperative morphine consumptionfirst 24 hours postoperatively

Contacts

CONTACTAbeer Ahmed, MD
abeer_ahmed@kasralainy.edu.eg+201005244590

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 2, 2026