Skip to content

THE EFFECTS OF HPV VACCİNATİON AND MESSAGE FRAMİNG

THE EFFECT OF GAIN AND LOSS FRAMING MESSAGES ON RISK PERCEPTION AND KNOWLEDGE LEVELS REGARDING HPV VACCINATION AMONG UNIVERSITY STUDENTS: A RANDOMIZED CONTROLLED TRIAL

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07614009
Enrollment
177
Registered
2026-05-29
Start date
2025-10-16
Completion date
2026-01-25
Last updated
2026-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Human Papillomavirus (HPV) Vaccination, Message Framing, Vaccination Intention

Keywords

message framing, gain-loss framing, human papillomavirus, vaccination, sex differences

Brief summary

Background: University students are at high risk for HPV infection, while HPV vaccination rates remain low. Message framing strategies may influence vaccination-related perceptions and intentions. Objective: This study aims to compare the effects of gain- and loss-framed HPV vaccination messages on HPV risk perception, HPV knowledge, and vaccination intention among university students. Methods: This randomized controlled experimental study includes university students from the health sciences faculty of a foundation university. Participants are assigned to gain-framed, loss-framed, and control groups. Data are collected using the Human Papillomavirus Knowledge Scale and the HPV Risk Perception Questionnaire. Statistical analyses include one-way ANOVA, two-way ANOVA, and Chi-square tests. The study is designed in accordance with CONSORT 2010 and EQUATOR Network reporting guidelines. Keywords: message framing; gain-loss framing; human papillomavirus; vaccination

Detailed description

This randomized controlled experimental study examines the effects of gain- and loss-framed HPV vaccination messages on university students' HPV knowledge, risk perception, and vaccination intention. A total of 927 university students were assigned to gain-framed, loss-framed, and control groups. The study evaluates the relationship between message framing and vaccination-related outcomes among university students.

Interventions

BEHAVIORALGain-Framed HPV Vaccination Message

Participants received gain-framed messages emphasizing the benefits of HPV vaccination.

BEHAVIORALLoss-Framed HPV Vaccination Message

Participants received loss-framed messages emphasizing the consequences of not receiving HPV vaccination.

Sponsors

Ankara Medipol University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Intervention model description

Participants were randomly assigned to gain-framed, loss-framed, and control groups in a parallel-group randomized controlled design.

Eligibility

Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes

Inclusion criteria

* Aged 18 years or older * Voluntarily agrees to participate in the study * Has not received formal education about HPV through a course or class

Exclusion criteria

* Has received the HPV vaccine * Has participated in formal education about HPV through a course or class * Has a current or previous positive HPV test result or HPV diagnosis

Design outcomes

Primary

MeasureTime frameDescription
HPV vaccination intentionImmediately after message exposureParticipant intention to receive the HPV vaccine measured immediately after message exposure using a self-reported vaccination intention scale.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 30, 2026