Thyroid and Parathyroid Surgery
Conditions
Keywords
chlordecone, thyroid nodes, thyroid disruptor
Brief summary
Chlordecone, an organochlorine pesticide used in the French Caribbean for several decades, is recognized as an endocrine disruptor. Accumulation in thyroid tissue may be modeled using several factors, including blood chlordecone levels, environmental exposure associated with place of residence, and dietary habits.
Detailed description
Chlordecone, an organochlorine pesticide, is recognized as an endocrine disruptor. Following ingestion, this molecule is preferentially stored in the liver and, to a lesser extent, in adipose tissue. The development of thyroid goiter may be promoted by exposure to certain substances. Environmental pollutants have been shown to increase TSH secretion, and prolonged exposure to endocrine disruptors affecting the pituitary-thyroid axis has been associated with thyroid neoplasia. Currently, exposure to chlordecone is assessed through measurement of chlordeconemia (plasma concentration), reflecting exposure during the months preceding sampling and providing an estimate of body burden at the time of assessment. However, chlordecone impregnation in thyroid tissue and adjacent structures has not yet been investigated in humans. The aim of this study is to model chlordecone concentration in tissues using chlordeconemia, occupational activity, dietary habits, and place of residence. A biological collection will be established and stored at the Biological Resources Center (CRB) of the University Hospital to support the primary and secondary objectives. Blood, adipose tissue, and thyroid tissue samples will be collected. The inclusion period will last 11 months, each participant will be involved for 4 months, and the total study duration will be 16 months.
Interventions
OTHERBlood and thyroid tissue collection
Collection of blood, thyroid tissue, and adjacent adipose tissue samples during routine thyroid surgery for measurement of chlordecone concentration and assessment of exposure-related factors.
Sponsors
Centre Hospitalier Universitaire de la Guadeloupe
Institut Pasteur de Guadeloupe
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Observational, analytical, single-center, cross-sectional study with prospective data collection.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adult patients hospitalized at the Guadeloupe University Hospital for surgical treatment of thyroid pathology * person affiliated to or beneficiaries of a social security system * person with free, informed, and written consent signed by the participant and the investigator
Exclusion criteria
* patients subject to a judicial safeguard measure, * patient under 18 years old * patient without signed consent * current pregnancy at the time of inclusion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| chlordecone concentration in the adipose tissue adjacent to the thyroid | During surgery | Chlordecone concentration measured in adipose tissue adjacent to the thyroid collected during thyroid surgery. |
| Chlordecone concentration in blood | 1 day before surgery | Chlordecone concentration measured in blood samples collected one day before surgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Occupational exposure category | At enrollment | Occupational activity classified as high or low potential exposure to chlordecone based on professional activity collected through a self-administered questionnaire. Agricultural workers and livestock breeders will be classified as high exposure occupations |
| Residential environmental exposure assessment | At enrollment | Environmental exposure assessment based on residential history during the previous 10 years. Residential addresses reported for periods longer than 3 months will be geolocated and linked to soil contamination maps established by CIRAD. |
| Dietary exposure assessment | At enrollment | Dietary habits assessed using a self-administered questionnaire collecting information on food consumption patterns and food origin. |
Countries
Guadeloupe
Contacts
CONTACTmélanie petapermal, Master degree
PRINCIPAL_INVESTIGATORsuzy Duflo, MD PhD
CHU de la Guadeloupe
Outcome results
None listed