Latent Tuberculosis Infection
Conditions
Brief summary
This retrospective observational single-center study aims to evaluate the medical and occupational relevance of systematic screening for latent tuberculosis infection using QuantiFERON-TB Gold Plus during pre-employment occupational health assessment among hospital workers at the University Hospital of Nice. Data will be collected retrospectively from occupational health medical records, immunology laboratory results and, when necessary, data from specialized follow-up by the tuberculosis control center. The primary objective is to determine the proportion of positive QuantiFERON-TB Gold Plus tests at pre-employment screening. Secondary objectives are to identify factors associated with a positive test, to describe the practical consequences of screening, including chest X-ray, diagnosis of latent tuberculosis infection and initiation of preventive treatment, and to estimate the cost of systematic screening.
Interventions
DIAGNOSTIC_TESTQuantiFERON-TB Gold Plus
Retrospective analysis of QuantiFERON-TB Gold Plus results performed as part of routine pre-employment occupational health screening. No additional diagnostic test or intervention will be performed for the purpose of the study.
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Newly recruited hospital workers at the University Hospital of Nice. * Workers who underwent pre-employment occupational health assessment during the study period. * Workers who had a QuantiFERON-TB Gold Plus test performed as part of pre-employment screening.
Exclusion criteria
* Incomplete or unusable occupational health records. * Indeterminate QuantiFERON-TB Gold Plus results will be included in the descriptive analysis but excluded from comparative analyses of test positivity.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of positive QuantiFERON-TB Gold Plus tests at pre-employment screening | At the inclusion | Percentage of positive QuantiFERON-TB Gold Plus |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association between risk factors and positive QuantiFERON-TB Gold Plus test | At the inclusion | Variables collected included age, sex, country of birth, previous stay in a high tuberculosis-incidence area, prior contact with tuberculosis, immunosuppression status, occupational category, and direct patient contact |
| Percentage of workers with clinical follow-up after positive QuantiFERON-TB Gold Plus test | From the positive QuantiFERON-TB Gold Plus test to completion of specialist follow-up. | Chest X-ray, referral to the tuberculosis control center or specialist consultation, final diagnosis of latent tuberculosis infection and initiation of preventive treatment. |
Countries
France
Outcome results
None listed