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Socket Preservation Using Autogenous Dentin

Socket Preservation After Tooth Extraction Using Autogenous Dentin in Comparison With Other Techniques

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07608289
Acronym
SPAD
Enrollment
80
Registered
2026-05-27
Start date
2025-01-01
Completion date
2028-12-31
Last updated
2026-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Extraction Site Healing

Keywords

Socket preservation, autogenous dentin, tooth extraction, alveolar ridge augmentation

Brief summary

Tooth extraction leads to a substantial reduction in alveolar bone volume, with up to 25% loss within the first year and up to 40-60% within three years. This prospective randomized clinical study aims to compare four commonly used methods of alveolar ridge preservation, evaluating their effectiveness in maintaining bone volume for later prosthetic or implant rehabilitation. Alveolar dimensions will be measured using calibrated CBCT imaging pre-extraction and at six months post-extraction.

Detailed description

The study evaluates four different approaches to alveolar ridge preservation after tooth extraction. Eligible patients aged 18-70 years will undergo minimally traumatic extraction. Four treatment modalities will be compared: 1) Spontaneous healing secured with a stitch (control group), 2) Application of collagen sponge (Parasorb Cone, Resorba, Germany) secured with a stitch, 3) Application of a tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic) covered with a collagen sponge (Parasorb Cone) and secured with a stitch. 4) Application of autogenous dentin, covered with a collagen sponge (Parasorb Cone) and secured with a stitch. Alveolar ridge dimensions will be measured on CBCT before extraction and again after six months. Primary outcomes include the absolute and relative change in ridge width and height at 1 mm, 3 mm, and 5 mm below the highest point of the alveolar bone as per Del Canto-Díaz, 2019. Patient factors (periodontal biotype, soft tissue phenotype, and vestibular thickness of the alveolar bone) will be recorded to allow subgroup analysis.

Interventions

PROCEDURETooth extraction left to heal spontaneously

Wound after the tooth extraction will be secured with a stitch without addition of any augmentation material.

PROCEDURETooth extraction plus collagen sponge

Wound after the tooth extraction will be filled with a collagen sponge (Parasorb Cone, Resorba, Germany) and secured with a stitch.

PROCEDURETooth extraction plus tricalcium phosphate

Wound after the tooth extraction will be filled with tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic), covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.

PROCEDURETooth extraction plus autogenous dentin

Wound after the tooth extraction will be filled with grounded autogenous dentin, covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.

Sponsors

University of Ostrava
Lead SponsorOTHER
University Hospital Ostrava
CollaboratorOTHER
Private dental practice Jalůvka
CollaboratorUNKNOWN

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* 18-70 years * no active periodontitis * signed informed consent with participation in the study * need for extraction of teeth other than third molars * patients requesting only standard/reimbursed care

Exclusion criteria

* drug or alcohol abuse * ongoing chemotherapy * ongoing radiotherapy * pregnancy * ongoing treatment of osteoporosis or other biological treatment with MRONJ risk * low compliance * patients asking for premium care

Design outcomes

Primary

MeasureTime frameDescription
Alveolar bone width6 monthsAbsolute and relative change in the alveolar bone width at 1 mm, 3 mm, and 5 mm below the alveolar crest measured from CBCT imagery.

Countries

Czechia

Contacts

CONTACTPetr Jalůvka, MDDr.
petr.jaluvka@osu.cz+420 596 623 518
STUDY_CHAIRMartin Starosta, Assoc. Prof.

University of Ostrava

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 28, 2026