Breast Cancer
Conditions
Brief summary
We consecutively enrolled patients presenting with breast space-occupying lesions at our hospital. Medical imaging data from simultaneously acquired ultrafast DCE-MRI, time-dependent diffusion MRI (TDD-MRI), magnetic resonance elastography (MRE), andvirtual magnetic resonance elastography(vMRE), along with clinical and pathological data, were collected. The study aims to evaluate and explore the clinical application value of these multimodal imaging techniques in the precision diagnosis, treatment, and prognosis of breast cancer. The findings are intended to provide a robust imaging basis for formulating and adjusting more precise, individualized treatment plans and prognostic assessments for patients. Ultimately, this research seeks to improve patient quality of life, optimize the allocation of medical resources, and advance the development of precision medicine.
Interventions
DIAGNOSTIC_TESTThe Value of Time-Dependent Diffusion MRI and Magnetic Resonance Elastography in the Precise Diagnosis and Efficacy Assessment of Breast Cancer
The MRI scan is part of the standard treatment protocol. Medical imaging data from simultaneously acquired ultrafast DCE-MRI, time-dependent diffusion MRI (TDD-MRI), magnetic resonance elastography (MRE), andvirtual magnetic resonance elastography(vMRE), along with clinical and pathological data, were collected.
Sponsors
Yunnan Cancer Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 years old 2. Female patients with BI-RADS class 4 or above breast lesions detected by mammography or ultrasound 3. Perform breast new technology MRI examination (ultra fast DCE-MRI、OGSE 、MRE、vMRE)within one week before biopsy or surgery
Exclusion criteria
1. Previously received breast radiotherapy, chemotherapy, surgery, or targeted therapy 2. Unable to cooperate in completing MRI examination 3. The image data contains serious artifacts (such as motion artifacts and metal artifacts), making it impossible to measure parameters 4. The lesion cannot be clearly identified and outlined on the image 5. Pregnant and lactating women 6. Combined with severe liver, liver, and kidney diseases, coagulation dysfunction, or other malignant tumors
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| efficacy evaluation | From enrollment to the end of surgery | For patients requiring neoadjuvant therapy, after completing the corresponding cycles of neoadjuvant treatment, the patient's surgical pathology results are used as the gold standard to assess tumor regression and determine whether pathological complete response (pCR) has been achieved. |
| Differentiation between benign and malignant lesions | From enrollment to the end of surgery | With puncture biopsy or surgical pathology serving as the gold standard, MRI parameters are used to distinguish benign from malignant lesions |
Countries
China
Contacts
CONTACTCaiyang Li
CONTACTZhenhui Z Li
Outcome results
None listed