Multiple Sclerosis
Conditions
Keywords
Exercise training, mobility disability, implementation
Brief summary
The purpose of this study is to establish differences in the primary outcome of walking dysfunction using the 12-Item Multiple Sclerosis Walking Scale (MSWS-12) and to establish differences in the secondary outcome of HRQoL using the 29-Item Multiple Sclerosis Walking Scale (MSWS-29) between the exercise training intervention condition and the waitlist control condition following the 16-week intervention period.
Interventions
BEHAVIORALExercise Training
Participants will then be mailed exercise materials in their preferred language, including the program manual, logbook, calendar, newsletters, Fitbit, and resistance bands, along with instructions for telephone or video conference calls. This is a 16-week, home-based program, supported remotely via Internet-based behavioral coaching, which integrates behavior change techniques based on Social Cognitive Theory (SCT)
Sponsors
The University of Texas Health Science Center, Houston
National Institutes of Health (NIH)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosis of MS * relapse-free in the past 30 days * self-identify as Hispanic/Latino * Patient Determined Disease Steps Scale (PDDS) score between 3.0 (gait disability) and 6.0 (bilateral support) indicates walking disability. * MSWS-12 score between 25 and 75, indicating walking disability * Willingness to complete the questionnaires and undergo randomization * English or Spanish as a primary language
Exclusion criteria
* significant exercise-related risk factors or contraindications, assessed individually using the Physical Activity Readiness Questionnaire (PAR-Q; requires clearance from physician).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in walking ability as assessed by the 12-Item Multiple Sclerosis Walking Scale (MSWS-12) | Baseline, 16 weeks, 32 weeks | This is a 12 item questionnaire and each is scored on a 5-point Likert scale from 1(not at all) to 5(extremely). Total raw scores ranging from 12-60 are converted into standardized scores from 0-100, with higher scores indicating greater perceived walking impairment related to multiple sclerosis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in HRQoL as assessed by the 29-Item Multiple Sclerosis Walking Scale (MSWS-29) | Baseline, 16 weeks, 32 weeks | This is a 29 item questionnaire and each is scored from 1( not at all) to 5(extremely) , with a Raw score range from 29 to 145. This is then converted into a standardized scale from 0 to 100, with higher scores indicating worse walking impairment and greater impact of multiple sclerosis on mobility. |
Countries
United States
Contacts
CONTACTStephanie L Silveira, PhD
CONTACTNajha Black
PRINCIPAL_INVESTIGATORStephanie L Silveira, PhD
The University of Texas Health Science Center, Houston
Outcome results
None listed