Brain Activity, Cognition
Conditions
Brief summary
Adult epilepsy patients who are undergoing intracranial monitoring will participate in a simple behavioral task during the clinical recording period.
Detailed description
The investigators will analyze recorded neural activity, eye movements, and behavioral responses from epilepsy patients undergoing intracranial monitoring with clinically-relevant microelectrodes in hippocampus that perform a decision-making task. The participants will perform 1 session of the task during their monitoring period. Behavioral responses will be fit to inference models to identify strategies subjects use, and neural recordings (neuronal firing and low frequency activity) will be correlated with task features by comparing results to those produced by randomized (bootstrapped) data. Neural activity and corresponding behavioral strategies for each participant will be used to refine theoretical recurrent neural network models of hippocampal engagement in multi-timescale inference.
Interventions
BEHAVIORALDecision-making task
Patients will be asked to play a decision-making game in which they hear a tone and must identify its source.
BEHAVIORALeye tracking
Patients will have simultaneous eye-tracking performed while playing the decision-making game
Sponsors
University of Colorado, Boulder
Study design
Observational model
CASE_ONLY
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Epilepsy patients undergoing intracranial electrode monitoring for uncontrolled seizures. * no lesions identified in the participants' brains * capable of giving consent
Exclusion criteria
* seizure activity during task recording * electrodes in regions of interest are identified to be the seizure focus * task performance outside of the normal range as determined from online studies with healthy participants
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pupil size changes with respect to task features | continuous recording during task, up to 30 minutes | pupil size will be measured with a portable eye-tracking device and correlated with task features |
| Behavioral Responses | Approximately 10 seconds per trial, up to 30 minutes total | Patient selects one of two choices on each trial using the computer keyboard |
| Intracranial electrode recordings to measure changes in brain activity during decision making | duration of the task, approximately 30 minutes | Intracranial neural recordings from patients who are implanted with electrodes for clinical purposes tha take place during the decision-making task |
Countries
United States
Contacts
CONTACTTahra Eissa
Outcome results
None listed