COPD (Chronic Obstructive Pulmonary Disease)
Conditions
Keywords
Muscle Strength, Functional Capacity, Pulmonary Rehabilitation, Interventional study, Adults, Exercise, Flywheel training, Lung Disease
Brief summary
Isoinertial training is emerging as a potentially effective strategy to improve strength and functionality in older people diagnosed with chronic obstructive pulmonary disease (COPD), due to its influence on muscle mass and neuromuscular efficiency. COPD is characterized by systemic alterations, including peripheral muscle dysfunction; which contributes to patient functional limitation, and reduces patients' quality of life. Isoinertial training may improve the physiological response to effort, and also promote functional performance in this population. Hence, the aim of this study is to evaluate the effect of an isoinertial training program on muscle strength and functional capacity in patients with COPD during an 8-week intervention.
Detailed description
To assess the effects of an isoinertial training programme on muscle strength and functional capacity in older people diagnosed with chronic obstructive pulmonary disease (COPD), in a randomized controlled clinical trial. Thirty participants diagnosed with moderate to severe COPD, over 50 years (50% men, 50% women), will be included to analyze possible differences in the training response compared to the control group. Participants will sign the informed consent and randomly assign to the intervention or control group. The intervention consists in a supervised isoinertial training program, while the control group will continue with the usual pulmonary rehabilitation program. Patients will be subjected to an initial assessment that include the application of tests of functional capacity, muscle strength, as well as clinical parameters and sociodemographic characteristics. The intervention will last 8 weeks, with a frequency of 2 to 3 sessions per week. The training program will include exercises aimed at strengthening the upper and lower limbs, using a isoinertial device with controlled load progression.
Interventions
DEVICEIsoinertial training
Supervised isoinertial training: * Participants will perform a supervised isoinertial training program during 8 weeks of follow-up * The intervention will have a frequency of 2 to 3 weekly sessions * The program will include exercises aimed at strengthening the upper and lower limbs using a isoinertial device * The training load will be progressive to each participant and adjusted according to the individual response. * The program will be carried out in combination with usual pulmonary rehabilitation care.
OTHERTraditional rehabilitation (control group)
Traditional treatment (control group) * Participants involved in the usual pulmonary rehabilitation program during 8 weeks with a frequency of 2-3 sessions per week. * This program includes low- to moderate-intensity aerobic exercise, joint mobility activities and general strengthening exercises using conventional resources according to the clinic's rehabilitation protocol. * No isoinertial training
Sponsors
Universidad Manuela Beltrán
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* People between 50 - 80 years of age diagnosed with moderate or severe COPD * No acute exacerbations in the last 4 weeks * Sufficient functional capacity to exercise * Signed informed consent
Exclusion criteria
* Presence of neurological, musculoskeletal, or cardiovascular diseases that significantly limit exercise performance or compromise participant safety; including uncontrolled hypertension, recent myocardial infarction, unstable angina, severe osteoarthritis, stroke sequelae, or Parkinson's disease. * Contraindications to exercise participation according to medical evaluation. * Recent surgeries in the past 3 months * Simultaneous participation in other exercise programs * Cognitive disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in upper limb muscle strength using the Hand Grip Test (HGT) | Baseline and 8-week follow-up | Manual grip strength will be evaluated by dynamometry, as an indicator of peripheral muscle strength in patients with COPD. |
| Change in functional capacity by 6-minute walk test (6MWT) | Baseline and 8-week follow-up | The distance covered for 6 minutes will be evaluated as an indicator of exercise tolerance and functional capacity. |
| Lower limb functional performance | Baseline and 8-week follow-up | The number of repetitions performed in 30 seconds will be recorded as an indicator of functional strength-endurance in the lower limbs |
| Change in functional mobility using the Timed Up and Go Test (TUG) | Baseline and 8-week follow-up | The time needed to get up from a chair, walk, turn and sit down again will be measured, as an indicator of mobility and functional risk. |
| Change in muscle quality index (MQI) | Baseline and 8-week follow-up | Muscle quality will be estimated using the MQI, which evaluates the muscle power of the lower limbs considering leg length, body mass, gravitational acceleration and time required to complete 10 sit-to-stand repetitions |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in functional performance using 5 Times Sit-to-Stand Test (5STS) | Baseline and 8-week follow-up | Time required to perform 5 repetitions of standing and sitting will be measured, as a complementary indicator of lower limb function |
| Change in health-related quality of life through The Saint George's Respiratory Questionnaire (SGRQ) | Baseline and 8-week follow-up | The SGRQ will be applied to assess the symptoms, activity and impact of the respiratory disease. This score ranges from 0 to 100 points, a higher score indicates poor health. |
| Changes in Body Mass Index (BMI) | Baseline and 8-week follow-up | Body mass index (BMI) will be assessed to characterize participants' anthropometric status. BMI will be calculated as body weight divided by height squared and expressed in kilograms per square meter (kg/m\^2). |
| Changes in heart rate | Baseline and 8-week follow-up | Heart rate (bpm) will be measured using an automatic monitor |
| Changes in blood pressure | Baseline and 8-week follow-up | Diastolic and systolic blood pressure (mmHg) will be measured using a blood pressure monitor |
| Changes in oxygen saturation (SpO2) | Baseline and 8 week follow-up | Oxygen saturation (Percentage, %) will be measured using an oximeter. |
Countries
Colombia
Contacts
CONTACTDavid Murcia-Lesmes, PhD
Outcome results
None listed