Epicardial Fat Tissue and Cardiometabolic Risk in Russian and Asian Populations

Epicardial Fat Tissue Assessed by Echocardiography in Russian and Asian Populations: Association With Chronic Non-Communicable Diseases and Risk Factors

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07604610

Acronym

EPIGRAPH

Enrollment

500

Registered

2026-05-22

Start date

2026-05-04

Completion date

2028-03-01

Last updated

2026-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Non-Communicable Diseases (NCDs), Epicardial Fat Tissue (EFT), Visceral Obesity

Keywords

epicardial fat, echocardiography, cardiovascular risk, metabolic disorders, cohort study

Brief summary

Visceral obesity is a well-established risk factor for the development of chronic non-communicable diseases (NCDs). Epicardial fat tissue (EFT) is located on the surface of the myocardium and may directly affect cardiac function and contribute to structural and functional remodeling. According to the literature, increased EFT thickness is associated with a wide range of NCDs, disease severity, and prognosis. The aim of this study is to investigate the associations between EFT thickness and clinical and anamnestic parameters, as well as to evaluate the prognostic value of this parameter in patients aged 50-70 years from the Russian Federation, Kazakhstan, Uzbekistan, and Kyrgyzstan.

Detailed description

The study is designed to: 1. Assess physical examination findings, laboratory parameters, and comorbidities; 2. Evaluate transthoracic echocardiography parameters; 3. Analyze associations between EFT thickness and clinical and anamnestic characteristics; 4. Determine threshold values of EFT thickness associated with structural and functional myocardial remodeling; 5. Conduct follow-up via telephone to assess study endpoints; 6. Evaluate the prognostic value of EFT thickness with respect to a composite endpoint.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

50 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Patients aged 50-70 years undergoing transthoracic echocardiography in inpatient or outpatient settings; * Ability and willingness to provide informed consent.

Exclusion criteria

* Refusal to sign informed consent; * Inability to perform transthoracic echocardiography or poor image quality; * Severe psychiatric disorders.

Design outcomes

Primary

Measure	Time frame
Composite endpoint - all-cause mortality - hospitalizations - major adverse cardiovascular events (MACE)	12 months

Countries

Russia

Contacts

CONTACTOlga Dzhioeva, MD, Associate Professor

odzhioeva@gnicpm.ru+79166141821

CONTACTElizaveta Rogozhkina, PhD

lizarogozkina@gmail.com+79371047331

Outcome results