Infection
Conditions
Keywords
Prediction model, MDRGNB, ICU, Infection
Brief summary
This prospective multicenter validation study aimed to evaluate the predictive performance of a previously developed model for MDRGNB infection in ICU patients.
Detailed description
Adult ICU patients were prospectively and consecutively enrolled across 11 research centers. MDRGNB infection risk predictions were generated within 24 hours of ICU admission using routinely available clinical data. Without interfering with clinical decision-making, the study assessed the discrimination, calibration, and clinical net benefit of the previously developed MDRGNB infection risk prediction model in real-world practice, applying the predefined threshold of 0.318.
Interventions
None listed
Sponsors
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Ruijin Hospital
Zhejiang Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years; * ICU stay ≥48 hours; * At least one clinical microbiological specimen collected and submitted for testing within 48 hours of ICU admission, with the first submission time designated as the index time; * Core predictive variables of the model extractable from electronic medical records or laboratory information systems.
Exclusion criteria
* For patients with multiple ICU admissions, only the first ICU stay was retained; * Missing or indeterminate primary outcome; * Missing key predictive variables that could not be handled according to prespecified rules.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MDRGNB infection | 48 hours after ICU admission | The objective of this study was to observe whether enrolled patients developed early MDRGNB infection and to validate the model's performance. The occurrence of MDRGNB infection was adjudicated by integrating clinical manifestations with culture results from collected specimens.Baseline and model variables: Collected within 48 hours of ICU admission.Primary outcome: Determined based on the results of the first submitted specimen. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 28-day mortality | 28 day after ICU admission | 28-day mortality |
| Sequential Organ Failure Assessment (SOFA) score at 48 hours | 48 hours after ICU admission | SOFA score at 48 hours, higher SOFA score mean a worse outcome |
| Adverse events related to antibiotic within 28 days | 28 day after admission | Adverse events related to antibiotic within 28 days, defined by Naranjo scale. |
Countries
China
Contacts
CONTACTDayu Chen, Pharmacist in Charge, PharmD
CONTACTJuan He, Professor, PharmD
Outcome results
None listed