Mild Cognitive Impairment (MCI), Stroke
Conditions
Brief summary
This study aims to investigate whether a combined intervention of mindfulness and dual-task training can improve cognitive function and physical performance in individuals with mild cognitive impairment after stroke.
Interventions
OTHERmindfulness
Guided by a professional mindfulness instructor, participants engage in mindfulness meditation to enhance attention, emotional regulation, and cognitive readiness. The training includes breath awareness, body scan, and present-moment awareness, delivered through guided meditation.Other Name:
DEVICEDual-Task Training
Dual-task training is a rehabilitation approach that targets cognitive-motor integration by requiring participants to perform a motor task and a cognitive task simultaneously. Examples include walking while performing mental calculations, memory tasks, or reaction-based exercises. The training is progressively adjusted by increasing task difficulty and cognitive load to improve attention allocation, executive function, and dual-task performance in daily activities.
DEVICEAerobic Training
Dual-task training is a rehabilitation approach that targets cognitive-motor integration by requiring participants to perform a motor task and a cognitive task simultaneously. Examples include walking while performing mental calculations, memory tasks, or reaction-based exercises. The training is progressively adjusted by increasing task difficulty and cognitive load to improve attention allocation, executive function, and dual-task performance in daily activities.
OTHERHealth education
Health education is a non-exercise control intervention designed to provide participants with knowledge related to post-stroke health management. Topics include stroke recovery, healthy lifestyle behaviors, nutrition, medication adherence, daily activity management, and psychological well-being. The intervention is delivered through structured educational sessions or instructional materials and does not include active physical or cognitive training components.
Sponsors
Nanjing Mingzhou Rehabilitation Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of stroke confirmed by computed tomography (CT) or magnetic resonance imaging (MRI). * Time since stroke onset ≥3 months and medically stable. * Presence of mild cognitive impairment after stroke, defined by a Montreal - - Montreal Cognitive Assessment (MoCA) score \< 26. * Mini-Mental State Examination (MMSE) score ≥ 24. * Ability to walk independently with or without an assistive device for at least 10 meters. * Stable medication regimen for at least 4 weeks prior to enrollment. * Ability to understand study instructions and provide written informed consent.
Exclusion criteria
* Severe aphasia, visual impairment, hearing impairment, or communication disorders that interfere with assessment or training participation. * Severe depression or other major psychiatric disorders. * Other neurological diseases affecting cognition or movement (e.g., Parkinson's disease, multiple sclerosis, traumatic brain injury). * Severe musculoskeletal, cardiovascular, or systemic diseases that contraindicate exercise participation. * Participation in other structured cognitive or rehabilitation intervention programs within the past 3 months. * Unstable medical condition or recurrent stroke during the study period. * Inability to safely complete the training protocol as determined by the study investigators.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Montreal Cognitive Assessment (MoCA) | From enrollment to the end of treatment at 4 weeks | The Montreal Cognitive Assessment (MoCA) is a widely used neuropsychological tool for detecting mild cognitive impairment (MCI). It assesses multiple cognitive domains, including attention, executive function, memory, language, visuospatial ability, abstraction, calculation, and orientation. The total score is 30 points, with higher scores indicating better cognitive function. |
Countries
China
Contacts
CONTACTJingzhi Zhang
Outcome results
None listed