Acute Ischemic Stroke, Cerebrovascular Event, Intracerebral Hemorrhage, Stroke, TIA (Transient Ischemic Attack)
Conditions
Brief summary
The overall objective of the study is to prospectively validate the diagnostic accuracy of the Stroke Mimics Score (SMS). This score is calculated using information collected at the time of the patient's arrival in the Emergency Department (triage) and may assist clinicians in distinguishing between: 1. cerebrovascular events (ischemic stroke, intracerebral hemorrhage, and transient ischemic attack \[TIA\]), 2. stroke mimics (i.e., conditions that present with stroke-like symptoms but without actual infarction of brain tissue). In addition, the study aims to compare its results with other existing tools and to evaluate its performance across different patient groups. Specifically, the present research seeks to generate data on the reliability of the SMS tool in providing an accurate diagnosis.
Interventions
None listed
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years at the time of presentation to the Emergency Department. * Presentation to the Emergency Department with a clinical suspicion of acute stroke, identified at nursing triage and/or through activation of the stroke pathway. * Presentation to the Emergency Department during the 6-month prospective enrollment period. * Feasibility of real-time collection of the data required to calculate the Stroke Mimics Score (SMS), including: age, systolic blood pressure, presence/absence of seizure at onset, presence/absence of headache at onset, presence/absence of confusion at onset, presence/absence of syncope at onset, presence/absence of isolated sensory deficit, presence/absence of motor deficit, history of coronary artery disease, history of prior stroke or transient ischemic attack (TIA). * Availability of a final hospital discharge diagnosis at the end of hospitalization or Emergency Department observation. * Signed informed consent from the patient or caregiver. If the patient is unconscious upon arrival at the Emergency Department, deferred consent will be applied.
Exclusion criteria
* Age \< 18 years. * Inability to fully collect the data required to calculate the Stroke Mimics Score (SMS). * Absence of a clearly defined final hospital discharge diagnosis. * Voluntary discharge, transfer, or death before completion of the diagnostic workup, in the absence of a reliable diagnosis. * Repeated Emergency Department visits for the same clinical event (only the first visit will be considered).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The rate of accuracy of Stroke Mimics Score (SMS) | through study completion, about 1 year | Diagnostic accuracy of the Stroke Mimics Score (SMS) in discriminating between: 1. cerebrovascular events (CVE), 2. stroke mimics (SM), assessed by: Area Under the Receiver Operating Characteristic Curve (AUROC). The AUROC will be calculated with a 95% confidence interval. An AUROC value significantly higher than 0.70 will be considered indicative of an acceptable discriminative ability of the score. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Analyses across clinical subgroups | through study completion, about 1 year | To evaluate sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), score calibration, the performance of the grouped version (SMSg), comparison with FABS and TMS, and analyses across clinical subgroups. |
Contacts
CONTACTGiovanni Frisullo
PRINCIPAL_INVESTIGATORGiovanni Frisullo
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Outcome results
None listed