Breast Cancer
Conditions
Keywords
Early breast cancer, breastfeeding, pregnancy, reproductive cycle
Brief summary
The incidence of breast cancer is increasing, particularly among young women. Cancers in young women are associated with a poor prognosis. The causes remain poorly understood. Among young patients, some are nulliparous and others have reported cancer during or after pregnancy. Preliminary studies suggest that breast tissue remodeling associated with pregnancy may influence the emergence and aggressiveness of early-onset cancers. However, breastfeeding and pregnancy are described as protective factors against the onset of breast cancer. The precise biology depending on age and the time between pregnancy and breast cancer is still poorly understood. The aim of our study is to increase our knowledge of cancer in young women and its potential links to pregnancy and breastfeeding. Information on the contraceptive habits and pregnancies of the patients in the study will be collected, and molecular and cellular analyses will be performed on frozen tumor samples as well as samples fixed and embedded in paraffin.
Interventions
OTHERNo Intervention: Observational Cohort
No intervention
Sponsors
Institut Cancerologie de l'Ouest
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
No minimum to 45 Years
Healthy volunteers
No
Inclusion criteria
* Triple-negative breast cancer or RH+/HER2- * Patient aged ≤ 45 years at the time of diagnosis ou Patient aged ≥ 55 years at the time of diagnosis
Exclusion criteria
* Availability of a diagnostic tumor sample
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| event-free survival | up to 5 years | event-free survival (time between diagnosis and the occurrence of the first event among the following: local recurrence, metastatic recurrence, death) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Describe the association between age at diagnosis and event-free survival (EFS) and overall survival. | up to 5 years | Describe the association between age at diagnosis and event-free survival (EFS) and overall survival (time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data) |
| Describe the association between previous pregnancy and overall survival according to age at diagnosis (≤45 years or ≥55 years). | Up to 5 years | Describe the association between previous pregnancy and overall survival according to age at diagnosis (≤45 years or ≥55 years). (Overall survival: time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data) |
| Describe the association between breastfeeding and EFS/overall survival in nulliparous women according to age at diagnosis (≤45 years or ≥55 years). | Up to 5 years | Describe the association between breastfeeding and EFS/overall survival in nulliparous women according to age at diagnosis (≤45 years or ≥55 years).(Overall survival: time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data) |
| Describe the association between age at first pregnancy (≥35 years, ≤35 years, nulliparity) and EFS/overall survival according to age at diagnosis (≤45 years or ≥55 years). | Up to 5 years | Describe the association between age at first pregnancy (≥35 years, ≤35 years, nulliparity) and EFS/overall survival according to age at diagnosis (≤45 years or ≥55 years).(Overall survival: time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data) |
Countries
France
Contacts
CONTACTMarie ROBERT, MD
CONTACTVincent GUEN, Ph D
PRINCIPAL_INVESTIGATORMarie ROBERT, MD
INSTITUT DE CANCEROLOGIE DE L'OUEST
Outcome results
None listed