Lynch Syndrome, Periodontal Disease
Conditions
Brief summary
The field of human microbiome research has undergone a revolution in its approach toward understanding how microorganisms influence the physiology of their host 1. The influence of the oral microbiota is not confined to this location 2. Periodontitis is a "chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by a progressive destruction of the tooth supporting apparatus"3. Given these observations, the central research question of the present study is to determine the prevalence of periodontitis in patients with Lynch syndrome (LS) compared with reference prevalence estimates from the general population40.
Interventions
OTHERperiodontal charting for the diagnosis of periodontitis
No additional interventions
Sponsors
Rotundo Roberto
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
1. Age ≥18 years; 2. All sexes eligible 3. Established diagnosis of LS performed as part of clinical practice, with a germline pathogenic/likely pathogenic variant in one of the following genes: MLH1, MSH2, MSH6, PMS2, and EpCAM 4. LS subjects undergoing surveillance gastrointestinal endoscopy according to clinical practice and international guidelines. 5. Subjects underwent dental and periodontal examination
Exclusion criteria
1. Age \< 18 years; 2. Absence of sufficient periodontal clinical or radiographic data to establish a periodontal diagnosis; 3. Subjects affected by systemic, autoimmune, chronic inflammatory, neurological, or severe psychiatric disorders, or by any other clinical condition that may interfere with study participation or data interpretation 4. Subjects with systemic conditions known to strongly affect periodontal status (e.g. uncontrolled diabetes, autoimmune inflammatory diseases, ongoing cancer therapy) were excluded to reduce major confounding factors that could independently alter periodontal outcomes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of periodontitis in Lynch Syndrome subjects. | Retrospective assessment at study enrollment | Diagnosis of periodontitis * Interdental clinical attachment loss (CAL) at ≥2 non-adjacent teeth * Buccal/oral CAL ≥3 mm with pocketing \>3 mm detectable at ≥2 teeth Clinical attachment loss = CAL = Distance between the cementoenamel junction and the base of the periodontal pocket (tip of the periodontal probe) |
Countries
Italy
Contacts
CONTACTProfessor Rotundo Roberto
Outcome results
None listed