Respiratory Tract Infections (RTI), Influenza -Like Illness, Influenza, COVID - 19, RSV Infections, Rhinovirus Infection, Metapneumovirus Infection
Conditions
Brief summary
Every year in the fall and winter, numerous respiratory viruses (such as influenza viruses, SARS-CoV-2 (COVID-19), RSV, rhinovirus, and metapneumovirus) circulate in mainland France, causing acute respiratory infections (ARIs). These viruses can cause epidemics of varying severity, requiring close monitoring to determine their circulation levels and adapt public health measures accordingly. In France, ARI surveillance relies on two networks: the Sentinelles network in primary care and the RENAL network in hospitals. The Sentinelles surveillance is conducted in collaboration with Santé publique France, the National Reference Center for Respiratory Infection Viruses (Institut Pasteur and Hospices Civils de Lyon), and the University of Corsica. As part of the virological surveillance of ARIs, Sentinelles physicians are asked to collect nasopharyngeal swabs or saliva samples from a sample of patients presenting with an ARI during their clinic visits. This surveillance makes it possible to identify respiratory viruses circulating in primary care (general practice and pediatrics), to describe confirmed cases for each of the circulating viruses, and to estimate the impact of each on general practice. This surveillance also allows for the evaluation of the effectiveness of vaccines against influenza and COVID-19.
Interventions
DIAGNOSTIC_TESTsaliva sampling
Based on the protocol, physicians perform either a nasopharyngeal swab or saliva collection on included patients. The method is determined by scientific data and epidemiological constraints, not by the patient. Saliva collection: The physician oversees the collection during the visit using the provided kit (pipette, tube, etc.). Depending on constraints, the patient may perform the collection at home if agreed upon. If the patient is unable to self-collect (e.g., infants, facial paralysis), the physician collects the saliva directly from under the tongue using the pipette.
DIAGNOSTIC_TESTNasopharyngeal swab
Based on the protocol, physicians perform either a nasopharyngeal swab or saliva collection on included patients. The method is determined by scientific data and epidemiological constraints, not by the patient. Nasopharyngeal sampling: During the consultation, the physician performs a deep nasal swab using the provided kit (FFP2 mask, swab, transport tube, absorbent, SafetyBag, and pre-paid envelope for partner labs).
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* be seen by a general practitioner or pediatrician participating in the Sentinelles surveillance program; * between week 40 (late September-early October) and week 15 (mid-April) of each year * have an acute respiratory infection (ARI) as defined below: Sudden onset of fever (or feeling of fever) and respiratory symptoms * have given oral consent to participate in this monitoring or, in the case of minors, oral consent given by the child's legal guardian(s) present at the consultation
Exclusion criteria
* a person who is subject to a court-ordered protective measure; * a person who is under guardianship or conservatorship, unless accompanied by their legal guardian or unless the legal guardian objects to their participation; * a person who is not in a condition to receive information or give consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of acute respiratory infection (ARI) cases seen in private practice (general practice and pediatrics) that tested positive for influenza viruses (by type and subtype), SARS-CoV-2, RSV, rhinovirus, and metapneumovirus | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| Weekly incidence rate of acute respiratory infections caused by influenza viruses and SARS-CoV-2 seen in general practice | Baseline |
| Proportion of patients included vaccinated against influenza | Baseline |
Contacts
CONTACTThierry BLANCHON, MD, PhD
CONTACTOlivier STEICHEN, MD, PhD
PRINCIPAL_INVESTIGATORThierry BLANCHON, MD, PhD
Institut National de la Santé Et de la Recherche Médicale, France
Outcome results
None listed