Stroke
Conditions
Keywords
Stroke, Muscle coordination, Visual feedback, Hand
Brief summary
The following experiment will be conducted with 15 chronic stroke survivors and 15 control subjects. Subjects will perform hand movements in the virtual reality environment using a head-mounted display. Quest's onboard cameras allow real-time tracking of hand motion, estimating joint angles of the finger and the thumb. For each feedback manipulation condition (i.e., movement amplification or reduction), the estimated joint angles will be multiplied by a factor greater than 1 (amplification) or a factor smaller than 1 (reduction). Then the newly-estimated hand posture will be displayed in the VR environment. Subjects will be randomly assigned into two groups (A and B), who will receive the assistance in a different order. Subjects will perform finger extension under three conditions: no sensory modulation, movement visual feedback (VF) amplification, and movement VF reduction (error augmentation), while their movement muscle activation patterns are recorded.
Interventions
DEVICEVisual ROM augmentation
Finger joint ROM is amplified.
DEVICEVisual ROM reduction
Visual feedback of finger joint ROM is reduced.
Sponsors
The Catholic University of America
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
for stroke group: * Age: 20 - 70 years old * First-ever unilateral cortical stroke with resultant hemiparesis at least 6 months prior to the experimental testing * Fugl-Meyer Upper Extremity Section 31 - 55
Exclusion criteria
for both groups: * Presence of concurrent severe medical illness * Pain in hand or arm with movements * Loss of voluntary control of fingers and thumb * Inability to provide informed consent * Musculoskeletal injuries (e.g., fracture) or medical complications (e.g., severe cardiovascular disease).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Joint range of motion (ROM) | Periprocedural | range of motion of individual finger joints under each condition, measured by embedded cameras that digitize individual finger segments |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Muscle activation | Periprocedural | Activation level of hand muscles will be measured using surface EMG electrodes attached to the major hand muscles including extensor digitorum communis, flexor digitorum superficialis, and first dorsal interosseous. |
Countries
United States
Contacts
CONTACTSang Wook Lee, PhD
Outcome results
None listed