HEMODYNAMIC RESPONSETO LYRANGOSCOPY AND ENDOTRACHEAL INTUBATION
Conditions
Brief summary
BLUNTING OF HEMODYNAMIC RESPONSE WILL BE OBSERVED IN PATIENTS NEBULISED WITH DEXMEDETOMIDINE AND NORMAL SALINE.
Detailed description
ONE GROUP OF PTS WILL BE NEBULISED WITH DEXMEDETOMIDINE AND OTHER WITH NORMAL SALINE AND WILL BE OBSERVED DURING AND AFTER INTUBATION FOR ATTENUATION OF HEMODYNAMIC RESPONSE FOR LYRANGOSCOPY AND ENDOTRACHEAL INTUBATION
Interventions
DRUGDexmeditomidine
dexmeditomidine 1mcg/kg diluted in 5ml 0.9% sodium chloride, administered via nebulizer over 5 minutes, 30 minutes prior to anesthetic induction .
normal saline 5 ml administered via nebulizer over 5 minutes, 30 minutes prior to anesthetic induction.
Sponsors
Shaheed Mohtarma Benazir Bhutto Institue of Trauma
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Participants were blinded to treatment allocation. Treatment was placed in sealed opaque envelopes and selected randomly. The outcome assessor who recorded blood pressure and heart rate was blinded to group allocation to minimize observer bias.
Intervention model description
Participants were randomly assigned to one of two parallel groups: Group A received nebulised dexmedetomidine 1 mcg/kg, and Group B received nebulised normal saline 5 ml. Both groups received intervention 30 minutes before induction of anesthesia.
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. Age 18-60 years 2. Either gender 3. ASA Physical Status I and II 4. Mallampati airway class I and II 5. BMI 18-30 kg/m2 6. Patients undergoing elective surgery under general anesthesia
Exclusion criteria
1. Patient refusal or lack of consent 2. Anticipated difficult airway 3. Intubation attempt lasting more than 15 seconds 4. Pregnancy 5. Uncontrolled hypertension, cardiac, pulmonary, hepatic, or cerebral events 6. Known allergy to dexmedetomidine or study drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in mean artirial pressure and heart rate after lyrangoscopy and intubation | baseline, 1 minute and 3 minute post intubation | hemodynamic stress response measured as change in mean arterial pressure and heart rate from baseline. MAP and HR will be recorded at baseline T0, 1 minute post intubation T1 ans 3 minute post intubation T3. Significant stress response is defined as rise in MAP nad HR more than 10% of baseline at 3 minutes post intubation. |
Countries
Pakistan
Outcome results
None listed