Lung Cancer
Conditions
Brief summary
This study targeted high-risk individuals with incomplete ablation and performed selective pulmonary artery embolization before lung cryoablation, which could enhance the therapeutic effect and reduce the risk of intraoperative bleeding. Previous studies have shown that selective pulmonary artery embolization before ablation has no adverse reactions related to embolization. In this study, gelatin sponge particles were used for selective pulmonary artery embolization. Gelatin sponge is an absorbable embolic material that can be absorbed and degraded in the human body within about 7 days, which has high safety and a low probability of adverse reactions. The surgical risks are detailed in the surgical protocol. The study aims to optimize the lung cryoablation strategy for high-risk individuals with incomplete ablation, aiming to improve the prognosis of high-risk recurrent patients. The two groups of patients underwent lung CT reexamination every three months after surgery to observe the tumor ablation situation.
Interventions
PROCEDUREPulmonary artery embolization
In this study, using DSA guidance, gelatin sponge particles were used to artificially embolize the thicker pulmonary arteries around the tumor, thereby reducing the heat sink effect and complications, and improving the efficacy of lung cryoablation.
Sponsors
Haibo Shao
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Individuals at high risk of incomplete ablation (for example, there are vessels with a diameter greater than 3mm within 1cm around the pulmonary nodule); 2. Scheduled for lung cryoablation, meeting the surgical indications and without any specific contraindications; 3. The long diameter of the lung tumor is less than 3cm; 4. The single cryoablation needle will be used. -
Exclusion criteria
1. Postoperative complications such as massive pneumothorax and bleeding occurred, which affected the observation of the ice ball's shape; 2. Poor image quality or incomplete images. -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ablation zone | Immediately assess the extent of the ablation after the ablation needle is withdrawn. | The CT images obtained during the operation are subjected to three-dimensional reconstruction, and the ROI is delineated. The long diameter, short diameter and volume of the ablation area are measured.Compare the values of various aspects of the smiling areas between the experimental group and the control group. |
Outcome results
None listed