Nicotine Use Disoder, Opioid Use Disorder
Conditions
Brief summary
This study examines the effects of e-cigarette (EC) flavors among adults with opioid use disorder (OUD) receiving buprenorphine treatment who currently use e-cigarettes. Participants will smell and rate 11 EC flavors based on appeal, sensory characteristics, and likelihood of future use. Researchers will examine how different flavor profiles influence the appeal and reinforcing effects of ECs in this population. The goal is to identify EC flavors that may enhance the acceptability of ECs as a potential harm-reduction strategy among adults with OUD receiving buprenorphine treatment.
Detailed description
This study examines the effects of e-cigarette (EC) flavors among adults with opioid use disorder (OUD) who are receiving buprenorphine treatment and currently use e-cigarettes. Participants will complete a brief session in which they will smell and rate 11 EC flavors based on their appeal, sensory characteristics, and likelihood of future use. Researchers will examine how different flavor profiles influence the appeal, positive subjective effects, and reinforcing potential of EC flavors in this population. The goal of the study is to identify one or more EC flavors that may enhance the acceptability and reinforcing effects of ECs as a potential harm-reduction strategy among adults with OUD receiving buprenorphine treatment.
Interventions
DRUGSweet-cooling
Sweet-cooling EC flavor
DRUGSweet non-cooling EC flavor
Sweet non-cooling flavor
DRUGTobacco flavor EC
Tobacco flavor EC
Sponsors
Prisma Health-Upstate
National Institute on Drug Abuse (NIDA)
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults aged 21 years or older. * Current e-cigarette users who report e-cigarette use on ≥20 of the past 30 days. * Former daily cigarette smokers who currently smoke on ≤19 days per month and no more than 5 cigarettes per day. * Diagnosed with opioid use disorder (OUD). * Currently receiving buprenorphine treatment for OUD.
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perceived Sweetness | Baseline session | Perceived sweetness of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not sweet at all" to "Extremely sweet," with higher scores indicating greater perceived sweetness. |
| Perceived Coolness/Freshness | Baseline session | Perceived coolness/freshness of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not cool/fresh at all" to "Extremely cool/fresh," with higher scores indicating greater perceived coolness/freshness. |
| Perceived Flavor Strength | Baseline session | Perceived flavor strength will be assessed using a one-item VAS ranging from "Very weak" to "Very strong," with higher scores indicating greater perceived flavor strength. |
| Perceived Harshness/Irritation | Baseline session | Perceived harshness/irritation of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not harsh/irritating at all" to "Extremely harsh/irritating," with higher scores indicating greater perceived harshness/irritation. |
| Flavor Liking | Baseline session | Flavor liking will be assessed using a one-item VAS ranging from "Not at all" to "Extremely," with higher scores indicating greater liking of the flavor. |
| Likelihood of Future Use | Baseline session | Likelihood of future use will be assessed using a one-item VAS ranging from "Not at all" to "Definitely," with higher scores indicating greater likelihood of future use of the flavor. |
Countries
United States
Outcome results
None listed