Alcohol Use Disorder (AUD)
Conditions
Keywords
Multiple Errands Test, Executive functions, Virtual reality, Alcohol Use Disorder
Brief summary
The goal of this study is to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive functions in patients with alcohol use disorder (AUD). More specifically, the project aims to: 1. evaluate if the performance in the virtual version of the test is related to the performance in the original test in patients with AUD. 2. establish whether the virtual version of the test is sensitive enough to detect patients with or without an executive function deficit. All participants will perform the original version (in a real-life supermarket) and the virtual version of the test (in a virtual reality environment). Performance in the two versions of the test will be compared. Participants will also complete a battery of neuropsychological tests and questionnaires.
Detailed description
The project aims to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive function in patients with alcohol use disorder (AUD), in comparison to the original test (MET), by: 1. establishing the ecological validity of the V-MET: a high correlation between performance on the MET and performance on the V-MET (total number of errors) in patients with TUAL and executive dysfunction. 2. establishing the sensitivity of the V-MET (to executive dysfunction): significant difference between V-MET performance in patients with an AUD and executive dysfunction versus (a) patients without executive dysfunction and (b) "healthy" volunteers
Interventions
BEHAVIORALMultiple Errand Test (MET)
The test takes place in a real supermarket. Participants must complete a list of tasks (e.g., purchasing certain items, collecting some information) while adhering to rules (e.g., not visiting the same place twice, etc).
BEHAVIORALVirtual MET
The test takes place in a virtual supermarket, developed on the C2Neuro app by C2CARE®. Participants must complete a similar list of tasks to the MET (e.g., purchasing certain items, collecting some information) and adhere to similar to rules (e.g., not visiting the same place twice, etc) .
Sponsors
Hôpital le Vinatier
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* written consent * Normal or corrected vision and hearing * Membership or entitlement to a social security plan * spoken and written French * third party liability insurance for patients only : * at least 6 criteria for AUD based on the Diagnostic and statistical manual of mental disorders * At the end of withdrawal: treatment with a diazepam equivalent of ≤ 20 mg/day
Exclusion criteria
* under tutorship/ judicial protection * Sensory or motor impairment (impeding the use of virtual reality and/or mobility) * Severe neurological disorder (such as dementia or Korsakoff's syndrome) * Photosensitive epilepsy (contraindication for the use of virtual reality) * Any other condition deemed incompatible with the study, at the investigator's discretion * Montreal Cognitive Assessment (MoCA) score \< 10 (severe cognitive impairment) * Breastfeeding or pregnant women * Familiarity with the supermarket visited during the MET test For controls only : * History of alcohol use disorder * score ≥ 8 on the Alcohol Use Disorders Identification Test * Score on the Frontal Assessment Battery \< 16 (or \< 15 if education is below secondary level)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total number of errors on the test | Baseline | Total number of errors on the MET and the V-MET. Errors include: * Inefficiencies (a more effective action could have been made) * Rule breaks: a specific rule is broken * Interpretation failure (the task is misunderstood or misinterpreted) * Task failure: not carried out or not completely completed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inefficiencies on the test | Baseline | Inefficiencies on the MET/V-MET : a more effective action could have been made Can be infinite |
| Rule breaks on the test | Baseline | Rule breaks on the MET / V-MET : a specific rule is broken |
| Interpretation failures on the test | Baseline | Interpretation failures on the MET/V-MET : the task is misunderstood or misinterpreted |
| Task failures on the test | Baseline | Task failures on the MET / V-MET : task not carried out or not completely completed |
Countries
France
Contacts
CONTACTLouis-Ferdinand LESPINE, PhD
CONTACTMéline Devaluez, PhD
PRINCIPAL_INVESTIGATORChristophe ICARD, MD
CH Le Vinatier
Outcome results
None listed