Bloodstream Infection, Pneumonia - Bacterial, S Maltophilia Infections
Conditions
Keywords
S. maltophilia, Infection, Mortality, Combined therapy
Brief summary
The goal of this multicentre observational study is to analyse the treatment strategies and the outcomes for patients with S. maltophilia infections using target trial emulation methodology. The main question it aims to answer is: • Does combined therapy achieve better results than monotherapy in treating S. maltophilia infections? Researchers will compare groups receiving monotherapy and combined therapy to see if there are differences in all-cause 30-day mortality.
Interventions
None listed
Sponsors
Instituto de Investigación Sanitaria Gregorio Marañón
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients * S. maltophilia infections * Different episodes if a new infection ocurred \> 30 days since the index episode
Exclusion criteria
* isolates obtained from patients outside of hospital admission * microbiological or clinical colonization * hospitalizations shorter than 72 hours since the time zero * patients who died in the first 72 hours since the time zero or who were in imminent risk of death * polymicrobial infections * receipt of inappropriate therapy after the time of the emulated randomization, defined as the absence of in vitro active antimicrobials or the administration of active antimicrobials for less than 48 hours * absence of data outcomes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality | At 30 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of complications | At 60 days | need for ICU admission and/or RRT, ECMO, recurrences, or in-hospital readmissions |
| Frequency of adverse events | At 60 days | — |
Countries
Spain
Contacts
CONTACTSofia de la villa Martinez, MD
Outcome results
None listed