General Anesthesia, Cervical Plexus Block, Thyroid Surgery
Conditions
Brief summary
The main aim of this study is to compare the effects of two different anesthesia methods-(1) general anesthesia alone and (2) combination of general anesthesia with cervical plexus block-on postoperative inflammatory process and amino acid metabolism in patients undergoing thyroidectomy.
Interventions
PROCEDUREGeneral Anesthesia
In our study, one patient group will receive only general anesthesia, while the other group will receive general anesthesia in addition to ultrasound-guided cervical plexus block. The inflammatory response is a natural response of the body's immune system to surgical trauma, and it can vary depending on the anesthetic agent used. In regulating this response, molecules such as IL-1β, TNF-α, IL-6, IL-10, and IL-40 are important indicators that determine the severity and duration of inflammation. These parameters will be examined and compared in both groups.
PROCEDUREcervical plexus block
In our study, one patient group will receive only general anesthesia, while the other group will receive general anesthesia in addition to ultrasound-guided cervical plexus block.
Sponsors
Harran University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* This includes patients aged 18-70 years * classified as ASA I-III * who have undergone elective thyroidectomy.
Exclusion criteria
* Patients who did not wish to participate in the study voluntarily * patients for whom superficial cervical block was contraindicated * pregnant and breastfeeding women * patients in ASA IV-V groups were excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perioperative Inflammatory Response | Before the procedure, and at 2 and 6 hours after the procedure. | IL-1β, TNF-α, IL-6, IL-10, and IL-40 levels will be measured 1 hour before surgery, and then 2 and 6 hours after surgery, and these values will then be compared. |
| Inflammatory Response | Before the procedure, and at 2 and 6 hours after the procedure. | IL-1β, TNF-α, IL-6, IL-10, and IL-40 levels will be measured 1 hour before surgery, and then 2 and 6 hours after surgery, and these values will then be compared. |
Contacts
CONTACTAbdulhakim Şengel
Outcome results
None listed