Irreversible Pulpitis (Toothache)
Conditions
Brief summary
The aim of the present study was to Correlate between the clinical presentation of pulp and the biological mediators in gingival crevicular fluid and the inflamed pulpal tissue.
Interventions
PROCEDUREroot canal treatment
root canal treatment for 2 groups , irreversible pulpitis and the other group is irreversible pulpitis with apical periodontitis
DIAGNOSTIC_TESTsamples from Gingival crevicular fluid
samples from the gingival crevicular fluid before and after endodontic treatment and from contralateral tooth
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
Systemically healthy male and female individuals aged between 18 and 50 years No physical or mental disabilities No underlying systemic diseases Mandibular permanent premolar teeth diagnosed with symptomatic irreversible pulpitis with apical periodontitis Mandibular permanent premolar teeth diagnosed with symptomatic irreversible pulpitis without apical periodontitis Diagnosis based on the terminology of the American Association of Endodontists (2009) Patients who provided written informed consent Fully developed teeth with no previous pulp exposure Positive response to cold testing Positive response to electric pulp testing
Exclusion criteria
Requirement for antibiotic prophylaxis Diabetes or hematologic disorders Use of anti-inflammatory drugs, antibiotics, or antidepressants within the previous four weeks Pregnancy at the time of treatment Heavy plaque or calculus accumulation Gingival redness and bleeding Severe gingivitis or generalized periodontitis Gingival pocket depths greater than 3 mm Negative response to sensibility testing (cold test or electric pulp testing) Presence of apical radiolucency (PAI \> 2) Previously initiated endodontic treatment Internal or external root resorption History of trauma Severe calcific metamorphosis with obliterated root canal spaces on periapical radiographs Vertical root fractures Mobility greater than Grade I (Miller's mobility index) Swelling or sinus tract associated with the treated tooth Presence of periodontal-endodontic lesions Teeth that could not be properly isolated with a dental dam Collection of less than 10 µL of blood from each site Conflicting clinical and radiographic findings preventing clear group assignment No bleeding from one or more canal orifices (possible partial necrosis)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| biological markers level | 2 months | TNF-alpha and sub P |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain score through the Visual analogue scale | 1 week | where the minimum reading is 0 and the maximum reading is 10 |
| clinical presentation of irreversible pulpitis | 1 week | Electric pulp tester |
Countries
Egypt
Outcome results
None listed