Evaluation of Slit-like Adjusted Mathieu Versus Onlay Island Flap for Hypospadias Repair in Pediatrics

Evaluation of Slit-like Adjusted Mathieu Versus Onlay Island Flap for Hypospadias Repair in Pediatrics: A Randomized Controlled Study

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07592026

Enrollment

Registered

2026-05-18

Start date

2020-05-01

Completion date

2025-10-31

Last updated

2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Narrow Urethral Plate Hypospadias

Keywords

Hypospadias, Slit-like Adjusted Mathieu, Onlay island flap, Urethroplasty, HOSE score

Brief summary

* Purpose\*\* To compare the Slit-like Adjusted Mathieu (SLAM) technique versus the inner transverse preputial onlay island flap for repair of anterior and mid-penile hypospadias with narrow urethral plate, evaluating complication rates, surgical outcomes, and cosmetic results. * Methods\*\* This prospective randomized controlled study included 80 patients with anterior and mid-penile hypospadias with a urethral plate \<6 mm, conducted at Al-Azhar University Hospitals, Cairo, Egypt, from May 2020 to October 2025. Patients were randomly allocated to SLAM repair (Group A, n=40) or inner transverse preputial onlay island flap (Group B, n=40). Follow-up ranged from 24 to 48 months. Outcomes were assessed using the Hypospadias Objective Scoring Evaluation (HOSE) questionnaire.

Interventions

PROCEDURESlit-like Adjusted Mathieu

Slit-like Adjusted Mathieu

PROCEDUREonlay island flap

inner transverse preputial onlay island flap

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

6 Months to 12 Years

Healthy volunteers

Inclusion criteria

* anterior or mid-penile hypospadias * shallow and narrow urethral plate measuring \<6 mm, * without or with mild penile curvature \<30° after degloving

Exclusion criteria

* wide urethral plate suitable for Tubularized Incised Plate (TIP) urethroplasty, * other types of hypospadias (penoscrotal, scrotal, or perineal), * moderate or severe penile curvature (\>30°) * recurrent cases

Design outcomes

Primary

Measure	Time frame
postoperative complications	Follow-up was performed at 1, 3, 12, and 24 months to assess complications

Secondary

Measure	Time frame	Description
Hypospadias Objective Scoring Evaluation score	at 12 months	a validated 5-point system, ranging from 5 to 16

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 19, 2026