Non-Alcoholic Fatty Pancreatic Disease, Polycystic Ovary Syndrome, Subclinical hypothyroïdism
Conditions
Brief summary
females of polycystic ovary syndromes may complain fatty pancreaetic disorder and thyroid hypofunctions (subclinical hypothyroidism)
Detailed description
females of polycystic ovary syndromes may complain fatty pancreaetic disorder and thyroid hypofunctions (subclinical hypothyroidism) will be divided to groups (twenty female for the group). groups will be treated with levothyroxine and metformin, but one of these groups will perform aerobic treadmill walking.
Interventions
BEHAVIORALphysical exercise program
twenty females of polycystic ovary syndromes may complain fatty pancreaetic disorder and thyroid hypofunctions (subclinical hypothyroidism)will be treated with daily dose of levothyroxine in addition to daily twotimes of 500-mg metformin, and these females will perform 50 minutes of aerobic treadmill walking hrice weekly for six month.
OTHERusual care
twenty females of polycystic ovary syndromes may complain fatty pancreaetic disorder and thyroid hypofunctions (subclinical hypothyroidism)will be treated with daily dose of levothyroxine in addition to daily two times of 500-mg metformin for six month.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* PCOS * fattty pancrease (non-alcoholic) * subclinical hypothyroid (signifcant with thyroid stimauted horomone more than 10 mIU/L) and normal non-disordered free thyroxine horomones
Exclusion criteria
* cardiac disesase * renal diseases * respiratory disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dehydroepiandrosterone | it will be measured after 6 months | it is a hormone involved in synthesis of sex hormones |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ratio of leutinzing hromone to hormone of follicels stimulatting hormones | it will be measured after 6 months | this ration express level of sex hormone |
| testesterone | it will be measured after 6 months | it is a sex horomone |
| body mass index | it will be measured after 6 months | it will be assessed on empty stomach and bladder |
| waist circumference | it will be measured after 6 months | it will be assessed on umblical levels |
| blood gluocose | it will be measured after 6 months | it will be assessed in fasting status |
| glycated hemoglubin | it will be measured after 6 months | it is an indiactor for longterm satus of blood gloucose |
| insulin | it will be measured after 6 months | it will be assessed in plasma |
| thyroid stimualtined horomone | it will be measured after 6 months | it will be assessed in plasma |
| triglyceridess | it will be measured after 6 months | it will be assessed in plasma |
| low densitiy liopporotein | it will be measured after 6 months | it will be assessed in plasma |
| cholesteroll | it will be measured after 6 months | it will be assessed in plasma |
| high densitiy lipoporteins | it will be measured after 6 months | it will be assessed in plasma |
| alanine transaminase | it will be measured after 6 months | it will be assessed in plasma |
| aspartatte transaminase | it will be measured after 6 months | it will be assessed in plasma |
Countries
Egypt
Contacts
CONTACTAli MA Ismail, lecturer
CONTACTali mohamed
PRINCIPAL_INVESTIGATORAli MA Ismail, lecturer
Cairo University
Outcome results
None listed