Gingival Recession
Conditions
Brief summary
Gingival recession (GR) is a term that describes the displacement of the gingival margin apical to the cemento-enamel junction (CEJ) of a tooth. The gold standard of GR treatment is surgical coverage through coronally advanced flap with subepithelial connective tissue graft (CAF+SCTG) (3). But, the need for a non-invasive technique for managing GR has not been frequently addressed. Phenytoin (PHT), used as an anti-seizure medication, has an established side effect of causing drug-influenced gingival enlargement. Its stimulatory effects on soft tissue metabolism suggested PHT to be tested topically for its effectiveness in wound healing. However, none of the previous studies that investigated topical phenytoin has assessed gingival recession; except for a case series.
Interventions
DRUGphenytoin cream
Phenytoin 1% paste
OTHERPlacebo
placebo paste
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients having gingival recession types RT1 and RT2 * Patients refusing surgical treatment options of their gingival recession.
Exclusion criteria
* Patients who underwent periodontal surgery in the affected teeth. * Patients with sensitivity to the medication used in the study. * Patients with systemic problems or administering drugs which could affect their periodontium or healing. * Pregnant or lactating women. * Smoking patients.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical Attachment loss | 3 months | measured by Periodontal probe (distance from cemento-enamel junction to base of the pocket) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| gingival recession | 3 months | Measured by periodontal probe (distance from gingival margin to cemento-enamel junction) |
| probing depth | 3 months | Measured by periodontal probe (distance from gingival margin to base of the pocket) |
| gingival thickness | 3 months | Measured by periodontal probe (is the probe visible during probing or not? Yes/No) |
| Keratinized tissue width | 3 months | Measured by periodontal probe |
| dentin hypersensitivity | 3 months | assessed by asking the patient if they feel sensitivity as binary outcome (yeas/no) and if yes, it is assessed by VAS |
Outcome results
None listed