D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients

Diaphragmatic Rapid Shallow Breathing Index (D-RSBI) Versus Traditional Rapid Shallow Breathing Index (RSBI) for Prediction of Weaning Success From Mechanical Ventilation in COPD Patients

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07590362

Enrollment

100

Registered

2026-05-15

Start date

2026-04-15

Completion date

2027-06-01

Last updated

2026-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease (COPD), Mechanical Ventilator Weaning

Keywords

D-RSBI, RSBI, COPD, Diaphragm Ultrasound, Mechanical Ventilation Weaning

Brief summary

This prospective observational cohort study aims to compare the predictive accuracy of diaphragmatic rapid shallow breathing index (D-RSBI) versus traditional rapid shallow breathing index (RSBI) for predicting weaning success from invasive mechanical ventilation in COPD patients. Diaphragmatic ultrasound measurements will be performed during spontaneous breathing trials, and patients will be followed for 72 hours after extubation to assess weaning outcomes.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Mechanically ventilated COPD patients fulfilling standard weaning readiness criteria. * Invasive mechanical ventilation for more than 24 hours before spontaneous breathing trial. * Hemodynamically stable without significant vasopressor support. * Adequate oxygenation with FiO2 ≤ 0.5 and PEEP ≤ 8 cmH2O . * Preserved mental status and ability to initiate spontaneous breathing. * Successful tolerance of spontaneous breathing trial conducted on CPAP mode with pressure support ≤ 8 cmH2O.

Exclusion criteria

* Refusal of consent * Neuromuscular disease, phrenic nerve palsy, or diaphragmatic paralysis. * Large pneumothorax or pathology interfering with ultrasound assessment. * Terminal extubation. * Recent major thoracic surgery. * Poor sonographic window despite repeated attempts.

Design outcomes

Primary

Measure	Time frame	Description
AUROC of D-RSBI for prediction of successful weaning	Within 72 hours after extubation	Area under the receiver operating characteristic curve (AUROC) of diaphragmatic rapid shallow breathing index (D-RSBI) for predicting successful weaning within 72 hours after extubation in mechanically ventilated COPD patients.

Secondary

Measure	Time frame	Description
AUROC of conventional RSBI for prediction of successful weaning.	Within 72 hours after extubation	Area under the receiver operating characteristic curve (AUROC) of conventional rapid shallow breathing index (RSBI) for predicting successful weaning within 72 hours after extubation in mechanically ventilated COPD patients.
Difference between AUROC values of D-RSBI and conventional RSBI	Within 72 hours after extubation	Comparison between AUROC values of D-RSBI and conventional RSBI for prediction of successful weaning.

Countries

Egypt

Contacts

CONTACTAhmed Atef Mohamed, MBBCh

ahmed_ateff_post@med.sohag.edu.eg+201006973892

Outcome results