Liver Cirrhosis, Liver Fibrosis
Conditions
Brief summary
This study is a multicenter, prospective study. In this study, enrolled subjects are cirrhotic patients of any etiology. The US and Sonazoid CEUS monitoring strategy was performed for cirrhotic patients: US and AFP joint with Sonazoid CEUS every 4 to 6 months, and combined CECT/CEMRI every 12 months.
Interventions
DIAGNOSTIC_TESTSonazoid CEUS
Sonazoid CEUS examination
Sponsors
Tianjin Third Central Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Cirrhotic patients diagnosed clinically or radiologically due to any etiology (patients with cirrhosis due to congenital fibrosis and patients with cirrhosis due to vascular causes were excluded). 2. Age 18-80 years old. 3. Able to receive regular imaging, including US, CEUS, and CECT or CEMRI or EOB-MRI, according to the diagnostic and treatment procedures. 4. Obtained informed consent from the patient.
Exclusion criteria
1. Patients with pathologic or enhanced imaging of established HCC who have not undergone curative treatment. 2. Patients with known hypersensitivity to enhanced imaging contrast agents. 3. Patients with severe cardiac, pulmonary or renal insufficiency that precludes CECT or CEMRI or EOB-MRI. 4. Lactating and pregnant women. 5. Those who are not suitable for enrollment as assessed by the investigator. 6. Patients with egg or egg-product allergy, or with severe right-to-left cardiac shunt or intrapulmonary shunt.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detection rate | 3-year | To compare the detection rate of Sonazoid CEUS and US for early HCC |
Countries
China
Outcome results
None listed