Acute Coronary Syndromes, Critical Limb Ischemia, Intermittent Claudication, Stable Coronary Artery Disease
Conditions
Brief summary
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages. This study aims to evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions, and to correlate these findings with the distribution of circulating monocyte subpopulations.
Interventions
DIAGNOSTIC_TESTOptical Coherence Tomography assessment
assessment of the number of infiltrating macrophages
Sponsors
Maria Cecilia Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with chronic coronary artery disease; * Patients with no-ST elevation acute coronary syndrome; * Patients with chronic claudication (Rutherford II-III) * Patients with critical limb ischemia (Rutherford IV-V).
Exclusion criteria
* Severe renal dysfunction * Severe valve disease * Advanced heart failure * Advanced liver disease * Chronic inflammatory or autoimmune disease * Use of antinflammatory drugs * Acute infection * Recent surgical procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| presence of macrophages and their activation within coronary and peripheral atherosclerotic lesions | From enrollment to hospital discharge following peripheral angiography/coronary angiography | To evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions (using OCT imaging), and to correlate these findings with the distribution of circulating monocyte subpopulations. |
Countries
Italy
Contacts
CONTACTRoberto Nerla, MD, PhD
Outcome results
None listed