Granulation Tissue From Residual Periodontal Pockets

Histological Analysis of Granulation Tissue From Residual Periodontal Pockets

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07587606

Acronym

GTRP

Enrollment

Registered

2026-05-14

Start date

2026-05-07

Completion date

2026-07-30

Last updated

2026-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Keywords

periodontitis, granulation tissue

Brief summary

This observational study aims to describe the histopathological features of granulation tissue (GT) found in residual periodontal pockets at the time of surgical intervention, after completion of the first two steps of periodontal therapy, according to EFP guidelines (Sanz et al., 2020). A secondary objective was to analyze GT characteristics in relation to clinical outcomes (e.g., defect type, probing depth reduction and clinical attachment gain) in order to identify possible statistical associations between tissue patterns and clinical improvements.

Detailed description

The study was conducted at the Section of Periodontology, Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Italy. Ethical approval was obtained from the Sapienza University Ethics Committee (6997 / 23-01-2023). Granulation tissue samples were collected during standard periodontal surgery from tissues that would normally be removed, without any additional intervention for the enrolled patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Age 18-75 years * Full Mouth Plaque Score (FMPS) \<15% at re-evaluation * Full Mouth Bleeding Score (FMBS) \<15% at re-evaluation * At least one site with probing depth (PPD) ≥5 mm after non-surgical therapy * Written informed consent * Good compliance throughout periodontal therapy

Exclusion criteria

* Pregnancy or breastfeeding * Use of systemic or local antibiotics in the previous 3 months * Smoking * Use of anti-inflammatory or anticoagulant/antiplatelet drugs * Systemic, cardiovascular, or infectious diseases affecting periodontal health * Dental contraindications to surgery (fractures, untreated endodontic lesions, mobility \> grade 2, or faulty restorations) * Non-compliant patients * History of periodontal therapy in the previous year * Ongoing orthodontic treatment

Design outcomes

Primary

Measure	Time frame	Description
Histopathological characterization of granulation tissue components	At time of surgery	Semiquantitative analysis (0-4 scale) of epithelial, subepithelial connective, deep connective, inflammatory, and osseous components in GT samples.

Secondary

Measure	Time frame	Description
Correlation between GT composition and clinical outcomes	At time of surgery	Assessed through statistical association analysis with probing depth reduction, clinical attachment gain and defect type

Countries

Italy

Outcome results