Skip to content

Long-term Effect of Silver Diamine Fluoride on the Dentin-Pulp Complex in Primary Teeth

Evaluation of the Long-term Effect of Silver Diamine Fluoride on the Dentin-Pulp Complex in Primary Teeth: A Histological Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07586631
Enrollment
6
Registered
2026-05-14
Start date
2026-01-29
Completion date
2026-05-15
Last updated
2026-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Silver Diamine Fluoride

Brief summary

Children with primary teeth with dentin carious lesions without pulp involvement, who have previously been treated with either Silver Diamine Fluoride (SDF) followed by Resin Modified Glass Ionomer or with Resin Modified Glass Ionomer alone, will be retrieved from the Pediatric Dentistry and Dental Public Health Department records. The aim of the study, a detailed description of the procedure, and how the tooth will be used, will be explained to the parents and their child, and written informed consent from the parents and assent from the child will be obtained.

Interventions

None listed

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
7 Years to 10 Years
Healthy volunteers
Yes

Inclusion criteria

\- Primary teeth that have previously been treated with either Silver Diamine Fluoride (SDF) followed by Resin Modified Glass Ionomer or Resin Modified Glass Ionomer alone.

Exclusion criteria

* Treated primary teeth with clinical or radiographic signs of infection

Design outcomes

Primary

MeasureTime frameDescription
Histological evaluation of dental pulp under light microscope7 days after extractionAfter teeth extraction, they will be fixed in a 10% formalin buffer for at least 48 hours, after which they will be decalcified in 10% nitric acid for 7 days. Then they will be embedded in paraffin, and mesiodistal histological sections approximately 8 μm thick will be cut. Sections will be stained with hematoxylin and Eosin, and a qualitative histological evaluation of dental pulp will be performed under light microscopy.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 15, 2026