AKI - Acute Kidney Injury, Critical Illness
Conditions
Keywords
AKI, CRRT, CKRT, Critical Illness, Intensive care
Brief summary
This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive care unit (ICU) length of stay (LOS).
Detailed description
This large national cohort study, including over 500,000 patients, aims to evaluate the association between time to initiation of continuous renal replacement therapy (CRRT) and intensive care unit (ICU) length of stay (LOS). The investigators hypothesize that earlier start of CRRT is associated with shorter length of stay among critically ill patients. CRRT is seen as a costly intervention, and after studies failing to demonstrate a mortality benefit from earlier initiation, the trend is to push, or postpone the start of CRRT. In Sweden the additional cost of CRRT amounts to around 5000 SEK, approximately 500 dollars/euros per 24 hours. However, the 24-hour cost of staying in the ICU is around 58000 SEK or 5800 dollars/euros.
Interventions
DEVICEcontinuous renal replacement therapy
We are evaluting early vs late initiation of CRRT
Sponsors
Karolinska Institutet
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with critical illness * Admitted to Swedish ICUs from 2010-2023 * Adult (18 years or older)
Exclusion criteria
\*Patients under 18 years of age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intensive care unit (ICU) length of stay (LOS) measured in hours | ICU LOS during the study period, from admission to discharge, average 168 hours (one week) | Hours from baseline, i.e. ICU admission (time=0) to ICU discharge (time=0+hours in ICU) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | ONE-YEAR Mortality post admission | Days from baseline, i.e. ICU admission to 30, 90,180 and 365 day mortality |
| Mechanical ventilation | Time on mechanical ventilation during the study period, average one week, but up to ICU discharge | Hours from baseline, i.e. start of ventilation (time=0) until end of ventilation, hours |
Contacts
CONTACTMax Bell, MD, PhD
PRINCIPAL_INVESTIGATORMax Bell, MD, PhD
Karolinska University Hospital
Outcome results
None listed