Symptomatic Apical Periodontitis
Conditions
Keywords
Postoperative Pain, Substance P, Calcium Hydroxide, Bioceramic intra-canal medication, BIO-C TEMP, Mandibular Molars, Intra canal medication, Endodontics, Root Canal Treatment, inflammatory mediators, Symptomatic Apical Periodontitis
Brief summary
Clinical Evaluation of the Postoperative Pain and Substance P levels Following the use of Bioceramic verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular molars with Symptomatic Apical Periodontitis
Detailed description
This study aims to evaluate postoperative pain levels and Substance P expression following the use of two different intracanal medicaments: bioceramic materials and calcium hydroxide in permanent mandibular molars diagnosed with symptomatic apical periodontitis. A total of 28 patients will be included in this study and randomly allocated into two equal groups (n=14 each). Group I will receive calcium hydroxide (Ca(OH)₂) as an intracanal medicament, while Group II will receive a bioceramic intracanal medicament. Standardized endodontic procedures will be performed for all participants. Postoperative pain will be assessed using a visual analog scale (VAS) at different time intervals following treatment. In addition, samples will be collected to evaluate Substance P levels as a biochemical marker associated with pain and inflammation. The comparison between the two groups will help determine the effectiveness of each intracanal medicament in reducing postoperative pain and inflammatory response. The results of this study may contribute to improving clinical decision-making in endodontic therapy.
Interventions
Calcium hydroxide will be used as an intracanal medicament during root canal treatment in Permanent Mandibular molars with Symptomatic Apical Periodontitis
DRUGBioceramic Intracanal Medicament
Bioceramic material will be used as an intracanal medicament during root canal treatment in Permanent Mandibular molars with Symptomatic Apical Periodontitis
Sponsors
Future University in Egypt
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Participants will be randomly assigned into two parallel groups to receive either calcium hydroxide or bioceramic intracanal medicament.
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* \- Patients aged 18-45 years with no sex predilection * Medically free Patients with no systemic conditions that can affect post operative pain response. * Patients should not be taking any pain medications 24 hours before intervention * Positive patients' acceptance for participating in the study * Patient able to sign informed consent * Permanent mandibular molars diagnosis with Symptomatic Apical Periodontitis * Permanent molars without any anatomical variations or severe curvatures
Exclusion criteria
* \- Medically compromised patients * Patients who have received antibiotic therapy within the last 2 weeks. * Pregnant or lactating women. * Patients with known allergy to any of the irrigants used. * Patients with swelling or acute peri-apical abscess or fistulous tract. * Teeth that have: * Wide or open apex . * Vital pulp tissue . * Periodontally affected with grade 2or 3 mobility. * Non restorable teeth . * Abnormal anatomy and calcified canals . * Pervious root canal treatment. * severe curved canal * Buccolingual and mesiodistal radiographs were taken to evaluate the root canal anatomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of postoperative pain levels | one week | Postoperative pain intensity will be assessed using the Visual Analog Scale (VAS), ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Pain scores will be recorded at 6 hours, 24 hours, 48 hours, 72 hours, and 7 days after treatment to compare postoperative pain levels between the two medicament groups and evaluate the correlation between Substance P reduction and pain perception. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| neurogenic biomarker Substance P Level | one week after the pulp Extirpation | To compare the effectiveness of bio ceramic intracanal medicament (Bio-C Temp) and calcium hydroxide in reducing the neurogenic biomarker Substance P in periapical samples of molars diagnosed with symptomatic apical periodontitis |
Contacts
CONTACTSalma Tarek Abdullah, Bachelors degree
PRINCIPAL_INVESTIGATORAdel Abdelwahed, Prof. Ass. of endodontic
Prof. Ass. of endodontic, faculty of Oral and Dental Medicine Future University in Egypt
PRINCIPAL_INVESTIGATORMarwa Moataz abo shadi, Lecturer of Endodontics
Lecturer of Endodontics, Faculty of Oral and Dental Medicine, Future university in Egypt
Outcome results
None listed