Acoustic Impedance Matching in ESWL Coupling

Acoustic Impedance Matching in ESWL: A Comparative Analysis of Hypotonic, Isotonic and Hypertonic Coupling Fluids

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07585435

Enrollment

294

Registered

2026-05-13

Start date

2023-07-01

Completion date

2026-02-28

Last updated

2026-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Stones

Brief summary

The purpose of this study is to investigate the effect of different salt concentrations (tonicity) in the coupling fluid used during Extracorporeal Shock Wave Lithotripsy (ESWL). The study compares three types of coupling fluids: hypotonic (degassed water), isotonic (0.9% NaCl), and hypertonic (3% NaCl) solutions. Researchers aim to determine which solution provides the best stone fragmentation success while minimizing procedure-related pain and skin complications.

Interventions

PROCEDUREHypotonic degassed water coupling

Hypotonic degassed water was used as the coupling fluid during the ESWL procedure.

PROCEDUREIsotonic (0.9% NaCl) coupling

0.9% NaCl (isotonic) solution was used as the coupling fluid during the ESWL procedure.

PROCEDUREHypertonic (3% NaCl) coupling

3% NaCl (hypertonic) solution was used as the coupling fluid during the ESWL procedure.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients with kidney stones measuring 5-20 mm. Patients scheduled for ESWL treatment. Age 18 and older

Exclusion criteria

Pregnancy. Uncorrected bleeding disorders. Active urinary tract infection. Anatomical abnormalities preventing ESWL.

Design outcomes

Primary

Measure	Time frame	Description
Stone Fragmentation Success Rate	2-4 weeks after the ESWL procedure	The percentage of patients achieving successful stone fragmentation, defined as residual fragments smaller than 4 mm.
Post-ESWL Pain Scores	Immediately after the ESWL procedure	Pain intensity assessed using the Visual Analog Scale (VAS), where 0 represents no pain and 10 represents the worst imaginable pain.

Countries

Turkey (Türkiye)

Contacts

PRINCIPAL_INVESTIGATORAhmet Murat Bayraktar, MD

University of Health Sciences, Konya City Hospital, Department of Urology, Konya, Turkey

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 14, 2026