Physical Activity in Persons With Parkinson's Disease

Physical Activity in Persons With Parkinson's Disease - a Longitudinal Cohort Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07585409

Acronym

ActivPARK

Enrollment

450

Registered

2026-05-13

Start date

2026-01-15

Completion date

2031-01-30

Last updated

2026-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PARKINSON DISEASE (Disorder), Physical Activity, Sedentary Behaviors

Keywords

Parkinson's disease, Physical activity, activity monitors, accelerometers

Brief summary

This project aims to identify why some people with Parkinson's disease (PwPD) become less physically active, and which factors support or hinder activity. Understanding these factors is essential for developing person centred interventions and effective support that can be implemented in routine healthcare. A national, multicentre longitudinal cohort study will be conducted including approx 450 PwPD from five Swedish regions (including the internal pilot NCT06901869). Physical activity will be measured objectively with activity monitors, combined with clinical assessments and digital questionnaires over four years. The primary outcome is physical activity level (accelerometer measured decline), and exposure variables include physical, cognitive, disease specific, social, environmental, motivational, and personal factors. Data collection involves clinical tests, questionnaires, accelerometer data, and patient reported experiences. This is a continuation of an internal pilot study NCT06901869. The study will enable early identification of those at risk for declining activity and guide development of person centred, evidence based interventions. Long term, it aims to integrate activity monitoring and risk factor screening into routine care to improve health and quality of life for PwPD.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* People diagnosed with idiopathic Parkinson's disease * Hoehn \& Yahr 1 to 4

Exclusion criteria

* Hoehn \& Yahr 5 (i.e. wheelchair bound or bedridden unless aided) * Unable to perform critical physical activity and clinical assessments

Design outcomes

Primary

Measure	Time frame	Description
Physical activity - low and moderate intensity	Baseline and yearly follow-ups for 3 years	The primary outcome is changes over time in PA (i.e. low + moderate-vigorous intensity PA in time spent per day) measured with accelerometers (Actigraph GT3X+, Pensacola, FL, US) during 7 days in people with Parkinson's disease everyday life.

Secondary

Measure	Time frame	Description
Physical activity - total vector magnitude	Baseline and yearly follow-ups for 3 years	The secondary outcomes are change over time in total vector magnitude measured with accelerometers (Actigraph GT3X+, Pensacola, FL, US) during 7 days in people with Parkinson's disease everyday life.
Physical activity - low intensity	Baseline and yearly follow-ups for 3 years	The secondary outcomes are change in time spent in low intensity physical activity per day measured with accelerometers (Actigraph GT3X+, Pensacola, FL, US) during 7 days in people with Parkinson's disease everyday life.
Physical activity - moderate high intensity	Baseline and yearly follow-ups for 3 years	The secondary outcomes are change in time spent in moderate-vigorous physical activity per day measured with accelerometers (Actigraph GT3X+, Pensacola, FL, US) during 7 days in people with Parkinson's disease everyday life.
Physical activity- sedentary	Baseline and yearly follow-ups for 3 years	The secondary outcomes are change in sedentary time per day measured with accelerometers (Actigraph GT3X+, Pensacola, FL, US) during 7 days in people with Parkinson's disease everyday life.
Physical activity - steps	Baseline and yearly follow-ups for 3 years	The secondary outcomes are change in steps per day measured with accelerometers (Actigraph GT3X+, Pensacola, FL, US) during 7 days in people with Parkinson's disease everyday life.

Countries

Sweden

Contacts

CONTACTCompliance Office Karolinska Insitutet

compliance@ki.se+46852480000

CONTACTErika Franzén

erika.franzen@ki.se+46852488878

PRINCIPAL_INVESTIGATORErika Franzén

Karolinska Institutet

Outcome results