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Interrupted 'Figure-of-X' Versus Continuous Suturing Technique for Abdominal Wall Closure in Colorectal Laparotomies

Interrupted 'Figure-of-X' Versus Continuous Suturing Technique for Abdominal Wall Closure in Colorectal Laparotomies: A Comparative Study on the Incidence of Burst Abdomen

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07585344
Acronym
X-CLOSURE
Enrollment
40
Registered
2026-05-13
Start date
2025-11-07
Completion date
2026-05-15
Last updated
2026-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

colorectal cancer, Figure-of-Eight, surgical wound dehiscence

Brief summary

This prospective randomized comparative study aims to evaluate whether interrupted figure-of-X fascial closure reduces the incidence of burst abdomen compared with continuous suturing in patients undergoing open colorectal laparotomy. Burst abdomen is a serious postoperative complication associated with increased morbidity, prolonged hospital stay, and reoperation. A total of 40 adult patients undergoing elective or emergency colorectal laparotomy will be randomized into two groups: interrupted figure-of-X closure or continuous fascial closure. The primary outcome will be the incidence of burst abdomen within 30 days after surgery. Secondary outcomes will include surgical site infection, seroma, hematoma, and length of hospital stay. The study is being conducted at the Department of General Surgery, Akbar Niazi Teaching Hospital, Islamabad, Pakistan.

Detailed description

Burst abdomen, also known as abdominal wound dehiscence, is a major postoperative complication following midline laparotomy. It is associated with increased postoperative morbidity, prolonged hospitalization, need for reoperation, and increased mortality. Although several abdominal wall closure techniques are currently practiced, the optimal method for preventing fascial dehiscence remains controversial. Continuous mass closure is commonly used because of its technical simplicity and shorter operative time. However, interrupted techniques, including interrupted figure-of-X suturing, may distribute tension more evenly across the wound and potentially reduce the risk of fascial disruption. Previous randomized and observational studies have shown inconsistent results regarding superiority of one closure technique over another, particularly in high-risk abdominal surgeries. This study aims to compare interrupted figure-of-X closure with continuous fascial closure in patients undergoing colorectal laparotomy. The study will be conducted as a prospective, randomized, single-center comparative trial at Akbar Niazi Teaching Hospital, Islamabad, Pakistan. After informed consent and eligibility assessment, 40 adult patients undergoing elective or emergency open colorectal laparotomy will be randomized in a 1:1 ratio into two groups: Group A: Interrupted figure-of-X fascial closure Group B: Continuous fascial closure Randomization will be performed using computer-generated permuted blocks with allocation concealment through sealed opaque envelopes. Surgeons cannot be blinded because of the nature of the intervention; however, postoperative outcome assessors and data analysts will remain blinded to group allocation. The abdominal fascia in both groups will be closed using slowly absorbable monofilament sutures according to a standardized operative protocol. Operative variables including suture material, bite spacing, operative duration, contamination level, and postoperative wound complications will be recorded. The primary outcome will be incidence of burst abdomen within 30 days following surgery. Secondary outcomes will include surgical site infection, seroma formation, hematoma, reoperation, and postoperative length of hospital stay. The findings of this study may help determine a safer and more effective abdominal wall closure technique in colorectal laparotomy patients and may contribute to improved postoperative surgical outcomes in high-risk populations.

Interventions

PROCEDUREInterrupted 'Figure-of-X' Suturing Technique

For the Figure-of-X: Specify the use of a "slowly absorbable monofilament suture" with "1 cm tissue bites and 1 cm spacing" in an interrupted X-pattern. For the Continuous closure: Specify the use of a "single-layer continuous mass closure" with the same suture material and spacing requirements

PROCEDURECONTINUOUS AMSS CLOSURE

The abdominal fascia is closed using a standard single- layer continuous (running) mass closure technique. A slowly absorbable monofilament suture is used to provide prolonged tensile strength. The technique follows a continuous suture line with approximately 1 cm tissue bites from the fascial edges and a 1 cm interval between each loop (travel). The suture is started at one end of the incision and continued to the other, ensuring even tension throughout the length of the midline laparotomy wound.

Sponsors

Islamabad Medical and Dental College
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Caregiver, Outcomes Assessor)

Masking description

While the operating surgeons cannot be blinded to the technique used, the ward staff (care providers), the outcomes assessor, and the statistician will remain blinded to the group assignment to minimize bias in wound assessment and data analysis.

Intervention model description

Participants will be randomized in a 1:1 ratio to undergo abdominal fascial closure using either interrupted figure-of-X suturing or continuous suturing following colorectal laparotomy. Outcomes will be compared between the two parallel study groups.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Adult patients (aged 18 years and above). * Patients undergoing open laparotomy for histologically confirmed colorectal cancer. * Elective surgical procedures.

Exclusion criteria

* Patients with a previous midline laparotomy within the last 30 days. * Patients in whom the abdominal wall is planned to be left open or managed with a temporary closure (open abdomen). * Patients with known connective tissue disorders (e.g., Ehlers-Danlos syndrome) that might impair wound healing. * Patients with an expected survival of less than 30 days. * Emergency laparotomies.

Design outcomes

Primary

MeasureTime frameDescription
THE INCIDENCE OF BURST ABDOMENUPTO 30 DAYS POST SURGERYThe number of participants experiencing postoperative disruption of the musculo-fascial layer (complete wound dehiscence) following midline laparotomy.

Secondary

MeasureTime frameDescription
Incidence of Surgical Site Infection (SSI)UPTO 30DAYS POST SURGERYOccurrence of infection at the surgical site, categorized as superficial, deep, or organ/space infection according to CDC criteria.
Postoperative Seroma and Hematoma FormationUp to 30 days post-surgery.Outcome Measure Description: The occurrence of fluid collection (seroma) or blood collection (hematoma) within the surgical wound.
Length of Hospital StayFrom date of surgery until date of discharge (approximately 7-14 days).The total number of days the participant remains in the hospital starting from the day of surgery until discharge.

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 27, 2026