Necrotic Teeth With Chronic Apical Periodontitis
Conditions
Keywords
Regeneration, Mature necrotic teeth, Nanochitosan, Inflammatory mediators
Brief summary
The goal of this clinical trial is to learn if nanochitosan can achieve regeneration in mature necrotic teeth. It will also provide data about the healing potential & postoperative pain after using different irrigation protocols. The main question it aims to answer are: Does nanochitosan can demonstrate clinically successful outcome, minimize postoperative pain & flare ups? What is the regenerative potential of mature necrotic teeth with chronic apical periodontitis? Is regeneration an alternative treatment modality for mature necrotic teeth with apical periodontitis? Researcher will compare the regenerative potential & postoperative pain after using 2.5% NaOCl+ 17% EDTA, 1% nanochitosan & 1% nanochitosan+17% EDTA to see if 1% nanochitosan alone or when used with 17% EDTA can enhance regeneration. Participants' root canals will be: Divided into 3 groups &irrigated thoroughly by the different irrigation protocols (2.5% NaOCl+ 17% EDTA, 1% nanochitosan & 1% nanochitosan+ 17% EDTA) Regenerative procedures will be done Clinical sensibility test & radiographic changes will be evaluated at 6&12 months follow up periods Detection of inflammatory mediators from GCF at 6 months follow up periods to be compared with its preoperative levels as a predictor for success or failure Assessment of postoperative pain using Numerical Rating Scale at 6, 12, 24 hours then daily for 7 days
Interventions
PROCEDUREIntervention 1: 1% nanochitosan
Irrigation with 1% nanochitosan
PROCEDUREIntervention 2: 1% nanochitosan & 17% EDTA
Irrigation with 1% nanochitosan \& 17% EDTA
Sponsors
Suez Canal University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
-adult patients in the age range 18-40 years with necrotic mature anterior teeth with chronic apical periodontitis as evidenced by apical radiolucency. * patients with good general health, without known systemic diseases or allergic reactions to any of the material used affecting healing outcome, with no sex predilection
Exclusion criteria
* medically compromised patients, systemic conditions e.g. uncontrolled diabetes or those on immunosuppressive drugs. * pregnant females * patients with generalized chronic periodontitis, mobility, and deep pockets * non-restorable teeth or teeth with open apices * teeth where post is needed to be restored or with previous root canal therapy * teeth with developmental anomalies, external and internal resorption
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of clinical success & healing of single visit regenerative endodontics in mature necrotic teeth with chronic apical periodontitis. | 1 year follow up | Clinical success will be evaluated via: 1. Sensibility tests using cold test (Endo Ice) \& electric pulp tester at 6 \& 12 months follow up periods. 2. Detection of molecular markers (inflammatory mediators) from the gingival crevicular fluid at 6 months follow up periods using ELISA. 3. Radiographic analysis of the changes in size of periapical lesion using Cone Beam Computed Tomography (CBCT) at 6 \& 12 months follow up periods. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative pain assessment after single visit regenerative endodontics in mature necrotic teeth with chronic apical periodontitis. | 1 year follow up | Postoperative pain will be assessed using Numerical Rating Scale by reporting pain levels at 6, 12, 24 hours, then daily for 7 days and comparing it with pain levels prior to the procedures. |
Countries
Egypt
Contacts
CONTACTSarah Hamed, M.D.Sc. in endodontics
Outcome results
None listed