Pregnancy Related
Conditions
Keywords
Pregnancy, Prenatal Nutrition, Neurodevelopment
Brief summary
The fetal brain requires DHA, choline, lutein, and zeaxanthin (L/Z) for development, dependent on maternal intake during pregnancy. However, many pregnant women do not meet daily requirements through diet or prenatal vitamins. Egg yolks are rich in choline, and women who consume eggs daily are more likely to meet the adequate intake of 450 mg/day. A recent study by Christifano et al. found that maternal egg and neuroprotective nutrient intake predicted neurodevelopment at 32 and 36 weeks of gestation. This study aims to determine if fetal neurodevelopment is enhanced among women who consume a prenatal diet emphasizing egg consumption (EGG) versus a healthy prenatal diet education control group (HPD). Women between 12-20 weeks' gestation will be randomized into EGG and HPD groups. The EGG group will receive education on the importance of prenatal choline and egg consumption and be encouraged to consume 10-14 eggs per week. The HPD group will receive education on a healthy prenatal diet. Both groups will be encouraged to take a DHA supplement, and dietary intake of choline, L/Z, and DHA will be collected. Fetal heart rate variability will be measured at 36 weeks gestation and infant EEGs will be conducted postnatally to examine brain function. Increasing prenatal egg consumption is both economical and feasible to boost prenatal choline intake, promote offspring neurodevelopment, and guide prenatal dietary recommendations.
Interventions
DIETARY_SUPPLEMENTEgg Supplementation
Encouraged to consume 10-14 eggs per week.
DIETARY_SUPPLEMENTHealthy Prenatal Diet
Educated on standard healthy prenatal diet and encouraged to follow recommendations.
Sponsors
University of Kansas Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Investigator)
Masking description
The Principal Investigator is blinded to participant intervention.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Pregnant females ≥18 years of age * 12 to 20-weeks' gestation at enrollment * No serious illnesses likely to confound study outcomes * Consuming 3 eggs/week or less at enrollment and willing to increase consumption during the study * Singleton gestation * Available by telephone and text
Exclusion criteria
* Less than 18 years at enrollment * Gestational age at enrollment \<12 or \>20 weeks * Any serious illness likely to confound study outcomes * Consuming more than 3 eggs per week at enrollment * Unable/unwilling to consume eggs until delivery or egg allergy * Expecting multiple infants * No access to telephone or text
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fetal neurodevelopment as indexed by heart rate variability (HRV) | 36 weeks gestational age | Group comparisons will be made between time-domain metrics of fetal HRV (SDNN, RMSSD) between those in EEG vs. HPD groups using a dedicated fetal heart rate monitor. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fetal neurodevelopment as indexed by heart rate variability (HRV) | 36 weeks gestational age | Relationship between intake of maternal neuroprotective nutrients, including choline, docosahexaenoic acid (DHA), lutein and zeaxanthin (L/Z) as measured by the Diet History Questionnaire-III and offspring neurodevelopment at 36 weeks gestation (fetal HRV). |
| Infant neurodevelopment as indexed by event-related potentials (ERP) | 1 month postnatal age | Brain neurophysiology will be measured at 1 month of age. Assessments of band-limited spectral power during resting-state will be assessed. Event-related potentials (ERP) to auditory stimuli will be recorded. Group comparisons will be made between measures of resting state spectral power and auditory ERP components. |
Countries
United States
Contacts
CONTACTNicole Mathis, MS
CONTACTLara Bennett, MS
PRINCIPAL_INVESTIGATORDanielle Christifano, PhD
University of Kansas Medical Center
Outcome results
None listed