Impact of the Procurement Technique on Outcomes After Liver Transplantation

Impact of the Procurement Technique on Outcomes After Liver Transplantation: a French Multicenter Prospective Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07582978

Acronym

PLVT_TH

Enrollment

1810

Registered

2026-05-13

Start date

2026-09-01

Completion date

2031-09-01

Last updated

2026-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplantation

Keywords

liver transplantation, LT, hepatocellular carcinoma (HCC), Arterial and Biliary Complication-Free Survival, procurement technique

Brief summary

Liver transplantation (LT) is the standard treatment for hepatocellular carcinoma (HCC) and end-stage liver disease, with excellent long-term outcomes despite the increasing use of extended criteria donors due to organ shortage. As traditional evaluation criteria have become insufficient, new indicators such as Arterial and Biliary Complication-Free Survival (ABCFS) have been developed to better assess post-transplant outcomes. Primary objective: To assess, in a large-scale study, whether the procurement technique influences liver transplantation outcomes in terms of arterial and biliary complication-free survival.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patients aged 18 years or older at the time of inclusion 2. Listed on the national waiting list of the Agence de la Biomédecine (ABM) 3. Undergoing a first liver transplantation in France 4. Receiving a whole liver graft 5. No prior or subsequent transplantation of another organ

Exclusion criteria

1. Pancreas procurement 2. Multiorgan transplantation 3. Split liver transplantation (shared grafts) 4. Retransplantation 5. Domino transplantation (no actual organ procurement in the conventional sense) 6. Patient refusal to allow the use of their data

Design outcomes

Primary

Measure	Time frame
Arterial and Biliary Complication-Free Survival (ABCFS) at 3 years	at 3 years post-transplantation

Secondary

Measure	Time frame	Description
Postoperative complications at 90 days	at 90 days post-transplantation	—
Type of Biliary complications	Up to 3 years post-transplantation	—
Type of Arterial complications	Up to 3 years post-transplantation	—
Occurrence of vascular injuries observed following organ procurement	Peri-procedural period (during procurement and immediately post-procurement)	—
Rehospitalization Rate Post-LT	Up to 3 years post-transplantation	Number of rehospitalizations per patient occurring after the initial transplantation hospitalization.
Duration of Rehospitalizations Post-LT	Up to 3 years post-transplantation	Length of stay for each rehospitalization occurring after the initial transplantation hospitalization.
Reasons for Rehospitalizations Post-LT	Up to 3 years post-transplantation	Reason for each rehospitalization occurring after the initial transplantation hospitalization, categorized by diagnosis.

Contacts

CONTACTEric Savier, MD, PhD

eric.savier@aphp.fr+33 1 42 17 56 90

CONTACTJinmi BAEK

jinmi.baek@aphp.fr

STUDY_CHAIRAstrid HERRERO, MD, PhD

Saint Eloi Hospital, Montpellier University Hospital

Outcome results