Autism Spectrum Disorder (ASD), Joint Attention
Conditions
Keywords
joint attention, ASD, eye tracking, fNIRS
Brief summary
This study set up two experiments using the free viewing video paradigm. By setting up social threat scenarios induced by humans (Experiment 1) and non social threat scenarios induced by objects (Experiment 2), combined with eye tracking and fNIRS technology, we explored the eye movement patterns and related brain activation characteristics of IJA in children with ASD.
Interventions
None listed
Sponsors
University of Electronic Science and Technology of China
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
3 Years to 10 Years
Healthy volunteers
Yes
Inclusion criteria
\- For ASD group: 1. 3 years ≤ age ≤ 10 years; 2. a diagnosis of autism spectrum disorder based on clinical symptoms, confirmed using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and other auxiliary diagnostic scales, including the Autism Diagnostic Interview-Revised (ADI-R) and the Childhood Autism Rating Scale (CARS); 3. further confirmation of ASD symptoms by experimenters with established research reliability using the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), with severity scores reported; 4. absence of comorbid physical diseases or other psychiatric disorders, including normal vision (or corrected-to-normal vision) and normal hearing; 5. no receipt of medication, transcranial magnetic stimulation (TMS), or transcranial direct current stimulation (tDCS) within the past three months. For TD group:The inclusion criterion for the TD group was a score below the cutoff on the Social Responsiveness Scale (SRS).
Exclusion criteria
\- For ASD group: 1. age \< 3 years or \> 10 years; 2. absence of a diagnosis of autism spectrum disorder based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and other auxiliary diagnostic scales, including the Autism Diagnostic Interview-Revised (ADI-R) and the Childhood Autism Rating Scale (CARS); 3. failure to meet diagnostic criteria after confirmation of ASD symptoms by experimenters with established research reliability using the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2); 4. presence of comorbid physical diseases or other psychiatric disorders, or problems with vision (or corrected-to-normal vision) and hearing; 5. receipt of medication, transcranial magnetic stimulation (TMS), or transcranial direct current stimulation (tDCS) within the past three months. For TD group: children were excluded if their scores on the Social Responsiveness Scale (SRS) exceeded the cutoff.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gaze transitions | The two time windows of 48-56 seconds and 70-80 seconds. | the number of transitions between face stimuli and unexpected stimuli |
| The proportion of fixation time | The two time windows of 48-56 seconds and 70-80 seconds. | The proportion of fixation time on AOI is calculated as the fixation time on AOI divided by the total valid fixation time on the screen within each phase |
| Activation concentration | The two time windows of 48-56 seconds and 70-80 seconds. | the concentration of cortical activation during video viewing |
Countries
China
Outcome results
None listed