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Sequential Prefrontal Alpha-Theta Neurofeedback on Abstinence Self-Efficacy, Mindfulness, and EEG in Alcohol Use Disorder

Effects of Sequential Prefrontal Alpha-Theta Neurofeedback Training on Abstinence Self-Efficacy, Mindfulness, and EEG in Alcohol Use Disorder

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07582692
Acronym
NFB-AUD
Enrollment
17
Registered
2026-05-13
Start date
2024-07-01
Completion date
2024-09-25
Last updated
2026-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol Use Disorder

Keywords

neurofeedback, EEG, abstinence self-efficacy, mindfulness, alpha-theta

Brief summary

This study examined the effects of sequential prefrontal alpha-theta neurofeedback training on abstinence self-efficacy, mindfulness, and brain electroencephalography (EEG) activity in adults with Alcohol Use Disorder (AUD). Participants in the experimental group received 24 sessions of neurofeedback over 8 weeks (3 sessions per week, 30 minutes per session), while a control group received no intervention. EEG and self-report measures were assessed at baseline and post-intervention.

Interventions

BEHAVIORALSequential Prefrontal Alpha-Theta Neurofeedback Training

Operant conditioning-based neurofeedback: 5 min alpha (8-12 Hz) + 25 min theta (4-7 Hz) at prefrontal sites Fp1/Fp2 per session; 24 sessions over 8 weeks supervised by a certified practitioner. Audio feedback (ocean waves for alpha, birdsong for theta) delivered via Power Nap device (Neuro21, Korea) while participants remained eyes-closed and seated.

Sponsors

Seoul University of Buddhism
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. Adults diagnosed with Alcohol Use Disorder (AUD) according to Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria 2. Alcohol Use Disorders Identification Test-Korean (AUDIT-K) score \>= 20 (males) or \>= 10 (females) indicating high-risk drinking 3. Voluntary written informed consent

Exclusion criteria

1. Sensory impairment (visual or auditory) 2. Diagnosis of intellectual disability 3. Current use of antipsychotics, central nervous system stimulants, or sedatives 4. Active neurological conditions (e.g., epilepsy, recent traumatic brain injury) 5. Severe psychiatric comorbidities (e.g., active psychosis) contraindicated for EEG-based neurofeedback

Design outcomes

Primary

MeasureTime frameDescription
Abstinence Self-EfficacyBaseline (Week 0) and post-intervention (Week 8)Total score on the Alcohol Abstinence Self-Efficacy Scale (AASE; Korean adaptation), a 20-item scale with four subscales (Negative Affect, Social/Positive Emotions, Physical and Other Concerns, Withdrawal and Urges), each rated 0-4; higher scores indicate greater confidence in maintaining abstinence.

Secondary

MeasureTime frameDescription
MindfulnessBaseline (Week 0) and post-intervention (Week 8)Total score on the Mindfulness Scale (20 items, 4 subscales: Decentered Attention, Nonjudgmental Acceptance, Present-Moment Awareness, Attentional Focus), rated 1-5 (reverse-scored); higher scores indicate greater mindfulness.
EEG Relative PowerBaseline (Week 0) and post-intervention (Week 8)Relative spectral power (% of total power) across delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (13-30 Hz), and sensorimotor rhythm (SMR; 12-15 Hz) bands at prefrontal sites (Fp1, Fp2), measured using eyes-closed resting EEG with the NeuroBrain system.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 14, 2026