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Data-Driven Lay First Responder Program in Cameroon

Implementation of a Data-Driven Pre-Hospital Lay First Responder Program in Cameroon

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07581327
Acronym
K-LFR Project
Enrollment
1812
Registered
2026-05-12
Start date
2026-09-01
Completion date
2028-09-01
Last updated
2026-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Injury, Trauma

Keywords

Lay First Resposnder, Trauma, Pre-Hospital care, Road Traffic Injury, By-stander response, Trauma systems, Emergency Care

Brief summary

Cameroon experiences a high burden of injury-related morbidity and mortality and currently lacks a formal pre-hospital care system. Lay First Responder (LFR) programs have been implemented in several low-and middle-income countries to improve early injury care by training non-medical community members with high exposure to injury, such as commercial drivers, in basic first aid and safe transport of injured patients. The study aims to implement and evaluate a data-driven, context-adapted LFR program in Cameroon using an implementation science approach. Quantitative trauma registry data and qualitative stakeholder interviews will be used to adapt the LFR curriculum to local injury patterns and care gaps. LFR program implementation will be associated with increased chances of survival on presentation and improved trauma outcomes. The study is an interrupted time series evaluation of an LFR intervention where prehospital care rates and clinical patterns in the Cameroon Trauma Registry (CTR) patients at Limbe Regional hospital will be compared between historical pre-implementation controls and post-implementation of a data-driven lay first responder training program (the intervention).

Detailed description

Injury accounts for a substantial proportion of preventable mortality in Cameroon, where no organized prehospital emergency medical system currently exists. Evidence suggests that effective prehospital care could prevent up to 45% of injury-related deaths. Lay First Responder (LFR) programs represent a pragmatic strategy for improving early trauma care in resource-limited settings by training lay persons who are frequently present at injury scenes. Despite promising early results in other settings, rigorous evaluation of LFR programs has been limited, particularly regarding their impact on patient-level outcomes. This study aim to test the contextual feasibility of the lay first responder program in Cameroon, after it has been successful in other Sub-Saharan nations. This study seeks to address these gaps by implementing a data-driven LFR program informed by trauma registry analysis and stakeholder engagement, and by evaluating feasibility, acceptability, and effectiveness within Cameroonian context. The Cameroon Trauma Registry (CTR) gathers prospective data on patient demographics, injury characteristics, receipt of prehospital care, clinical findings and management, disposition and outcomes on patients admitted for injuries at ten trauma hospitals in Cameroon. Each hospital has a full-time research assistant overseen by an MPH-level field supervisor. Patients are followed from presentation through hospital discharge. This study will be implemented in Limbe municipality, Cameroon and will utilize data from the Limbe Regional Hospital site of the CTR. The LFR intervention: An LFR curriculum adapted for the Cameroon context using a two-stage, mixed-methods approach (quantitative analysis of prospective CTR data and qualitative semi-structured interviews of target stakeholders) will be used to train LFR providers (commercial drivers and community members) over a 3-month training and transition period. The primary metric of program feasibility will be percent change in the proportion of trauma patients receiving prehospital care in the post-intervention cohort compared to pre-intervention historical controls. The secondary outcomes for program effectiveness will be injury severity-stratified percentage change in the proportion of CTR patients presenting with normal vital signs (systolic blood pressure, heart rate, respiratory rate) in the post-intervention cohort compared to the pre-intervention cohort.

Interventions

BEHAVIORALLay First Responder (LFR) training

Training of LFR providers using a data driven, pretested curriculum adapted for the Cameroon context over a 3-month training and transition period.

Sponsors

Sabrinah Christie
Lead SponsorOTHER
Fogarty International Center of the National Institute of Health
CollaboratorNIH
University of Buea
CollaboratorOTHER
University of California, Los Angeles
CollaboratorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE

Intervention model description

The study is an interrupted time series evaluation of a Lay First Responder (LFR) training program where prehospital care rates and clinical patterns of injured Cameroon Trauma Registry patients at Limbe Regional hospital will be compared between historical pre-implementation group and post- implementation cohort of the LFR training (the intervention).

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

\- Trauma patients presenting to Limbe Regional Hospital and enrolled in the Cameroon Trauma Registry

Exclusion criteria

\- Trauma patients not included in the Cameroon trauma registry at Limbe regional hospital.

Design outcomes

Primary

MeasureTime frameDescription
Prehospital care rateFrom enrollment through the 18-month post implementation period.Proportion of hospitalized trauma patients who received prehospital care prior to arrival at participating hospitals, compared between pre- and post implementation LFR cohorts.

Secondary

MeasureTime frameDescription
Systolic blood pressure at presentationFrom enrollment through the 18-month post implementation period.Median systolic blood pressure (mmHg) measured at hospital presentation among injured patients, compared between pre- and post implementation LFR cohorts
Respiratory rate greater than 8 and less than 20 breaths per minuteFrom enrollment through the 18-month post-implementation periodPercentage change in the proportion of CTR patients presenting with respiratory rate greater than 8 and less than 20 breaths per minute compared between pre- and post implementation LFR cohorts.
Proportion of trauma patients with heart rate between 60 and 100 beats per minuteFrom enrollment through the 18-month post implementation period.Percent change in the proportion of trauma patients with heart rate between 60 and 100 beats per minute compared between pre- and post implementation LFR cohorts.
In-hospital mortalityFrom enrollment through the 18-month post-implementation period.All-cause in-hospital mortality among injured patients, compared between pre- and post implementation LFR cohorts.
24-hour mortalityFrom enrollment through the 18-month post implementation period.All-cause mortality within 24 hours of hospital presentation among injured patients, compared between pre- and post implementation LFR cohorts.
Blood transfusionFrom enrollment through 18-month post implementation period.Proportion of injured patients receiving blood transfusion during hospitalization, compared between pre- and post implementation LFR cohorts.
Operative interventionFrom enrollment through 18-month post implementation period.Proportion of injured patients requiring surgical intervention during hospitalization, compared between pre- and post implementation LFR cohorts.

Countries

Cameroon

Contacts

CONTACTS.Ariane Christie, BA, MD
s.ariane.christie@gmail.com808-430-9678
CONTACTIsaac Obeng-Gyasi, MBChB, MPH
iobeng@mednet.ucla.edu202-500-4230

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 13, 2026