Frailty, Neuromuscular Blockade, Pharmacodynamics, Rocuronium, Sarcopenia
Conditions
Brief summary
This prospective observational study aims to evaluate whether sarcopenia and frailty affect the pharmacodynamic profile of rocuronium in geriatric patients undergoing elective surgery under general anesthesia.
Interventions
None listed
Sponsors
Konya Meram State Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Scheduled to undergo elective surgery under general anesthesia requiring endotracheal intubation * Planned use of rocuronium for neuromuscular blockade * Quantitative neuromuscular monitoring planned during anesthesia * American Society of Anesthesiologists physical status I-III * Ability to provide written informed consent * Completion of preoperative frailty and sarcopenia assessment
Exclusion criteria
* Emergency surgery * Known neuromuscular disease * History of allergy or contraindication to rocuronium, sugammadex * Severe hepatic insufficiency * Severe renal insufficiency * Use of drugs known to significantly affect neuromuscular transmission * Preoperative mechanical ventilation or intensive care unit admission * Inability to perform a frailty or sarcopenia assessment * Patients in whom quantitative neuromuscular monitoring cannot be properly performed * Refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rocuronium onset time | Perioperative/Periprocedural - during anesthesia induction | Time from intravenous administration of rocuronium to disappearance of all train-of-four responses, defined as train-of-four count 0, measured using quantitative neuromuscular monitoring |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time from train-of-four count 0 to train-of-four count 2 | From achievement of train-of-four count 0 after the initial rocuronium dose until recovery of train-of-four count 2 during surgery | Time elapsed from achievement of train-of-four count 0 after the initial rocuronium dose to recovery of train-of-four count 2, recorded in minutes and measured using quantitative neuromuscular monitoring. |
| Time to train-of-four ratio 0.9 after sugammadex administration | From sugammadex administration until recovery of train-of-four ratio to 0.9 at the end of surgery | Time from sugammadex administration to recovery of train-of-four ratio to 0.9, measured using quantitative neuromuscular monitoring. |
| Total rocuronium dose | From anesthesia induction until the end of surgery | Total dose of rocuronium administered during anesthesia |
Countries
Turkey (Türkiye)
Contacts
PRINCIPAL_INVESTIGATORBetül Kozanhan, M.D.
SBÜ Konya EAH
Outcome results
None listed