Critical Illness, Frailty, Intensive Care Unit (ICU)
Conditions
Keywords
CALLY index, frailty, SOFA-2 score, ICU mortality, Geriatric patients
Brief summary
This study aims to evaluate the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index, Clinical Frailty Scale (CFS), and SOFA-2 score in predicting mortality among geriatric intensive care unit (ICU) patients. The primary outcome is ICU mortality. Secondary outcomes include 28-day mortality, ICU length of stay, duration of mechanical ventilation, need for renal replacement therapy, and vasopressor requirement. The study also investigates whether the combined use of these parameters improves predictive performance compared to conventional scoring systems such as APACHE II.
Detailed description
This is a single-center, prospective observational cohort study including patients aged ≥65 years admitted to the intensive care unit. Demographic characteristics, comorbidities, frailty status (Clinical Frailty Scale), and severity scores (SOFA-2, APACHE II) will be recorded. Laboratory parameters including C-reactive protein, albumin, and lymphocyte count will be used to calculate the CALLY index within the first 24 hours of ICU admission. Patients will be followed for ICU mortality and 28-day mortality. Additional outcomes include ICU and hospital length of stay, duration of mechanical ventilation, vasopressor requirement, and need for renal replacement therapy. Statistical analyses will include logistic regression and receiver operating characteristic (ROC) curve analysis to evaluate the predictive performance of each parameter and their combined use.
Interventions
OTHERobservational study
No intervention is applied.This is an observational study in which patients receive standart clinical care.
Sponsors
Istanbul University - Cerrahpasa
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥65 years * Admission to the intensive care unit * Availability of required clinical and laboratory data within the first 24 hours of ICU admission
Exclusion criteria
* Death within the first 24 hours after ICU admission * Missing key clinical or laboratory data * Terminal malignancy receiving palliative care
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ICU Mortality | From ICU admission until ICU discharge or death, assessed up to 28 days | All-cause mortality occurring during the intensive care unit stay. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 28-day Mortality | 28 days | All-cause mortality within 28 days after ICU admission. |
| ICU Length of Stay | From ICU admission until ICU discharge or death, assessed up to 28 days | Duration of stay in the intensive care unit, measured in days. |
| Hospital Length of Stay | From hospital admission until hospital discharge or death, assessed up to 28 days | Total length of hospital stay, measured in days. |
| Duration of Mechanical Ventilation | From initiation of invasive mechanical ventilation until discontinuation, assessed up to 28 days | Total duration of invasive mechanical ventilation, measured in days. |
| Vasopressor Requirement | From ICU admission until ICU discharge or death, assessed up to 28 days | Requirement for vasopressor support at any time during ICU stay. |
| Renal Replacement Therapy Requirement | From ICU admission until ICU discharge or death, assessed up to 28 days | Requirement for renal replacement therapy (RRT) during ICU stay. |
Countries
Turkey (Türkiye)
Outcome results
None listed