Hyperlipidemias
Conditions
Keywords
Withania somnifera, Syzygium cumini, hyperlipidemia
Brief summary
Withania somnifera and Syzygium cumini are known for their potential therapeutic effects, particularly in managing lipid disorders. This study was aimed to provide valuable insights into their separate and synergistic effect of Withania somnifera (Ashwagandha) and Syzygium cumini (Jamun) on hyperlipidemic patients. The study included 60 patients, equally divided into four groups. Pre- and post-treatment assessments were conducted over 3 months. Each group recieved different treatment. Data was analyzed using SPSS version 21 through paired sample t-test. The findings of the research showed that Withania somnifera showed significant improvement in improving lipid profile and associated factors and concluded that the combination may be an effective and safe approach for managing hyperlipidaemia due to its beneficial impact on lipid profile.
Detailed description
Hyperlipidemia is a defect of lipid metabolism with high levels of total cholesterol, triglycerides and low-density lipoprotein and reduced high-density lipoprotein levels. In Pakistan, the overall prevalence of dyslipidemia was determined to be 96%. Diabetes, obesity and hypertension were discovered as important risk factors. According to WHO, around 80% of population globally believes in botanical drugs and for many years they are using plants extract and their components for managing dyslipidemia. Withania somnifera, popularly known as "Ashwagandha" is rich in phytochemicals and terpenoids. Its root powder has been effective in decreasing total lipids, cholesterol and triglycerides and can increase high-density cholesterol levels. In addition, Syzgium cumini, commonly known as "Jamun". Its seeds possess lipid lowering properties and are able to reduce ratio of total serum cholesterol and high-density lipoprotein cholesterol, serum low density lipoproteins and triglycerides level. This study was therefore aimed to provide valuable insights into their separate and synergistic effect of Withania somnifera (Ashwagandha) and Syzygium cumini (Jamun) on lipid profile and associated factors including body weight, body mass index (BMI) and blood pressure. The study design was a Randomized Controlled Trial. The data was collected from Mukhtiar Munir Hospital. Patients that were selected were given Withania somnifera and Syzgium cumini capsules (500mg BD) daily separately and in combination (1000 mg QD) for a duration of 3 months. Before intervention patients were assessed and then after 6 weeks reassessment was done. After the completion of 12 weeks patients' weight, BMI, lipid profile and blood pressure were assessed again. Data was recorded using Excel and IBM-SPSS statistical software version 21.0. Frequencies and percentages were recorded for baseline characteristics on SPSS descriptive scale. The means of two measurements (pre- and post-intervention) of each variable made of the same person were compared using the paired sample T-Test. Statistics were considered significant for p-values less than 0.05.
Interventions
In this intervention, participants were instructed to take their usual medication for hyperlipidemia they were taking before.
DIETARY_SUPPLEMENTGroup B (treatment group 1)
In this intervention, participants were instructed to take Withania somnifera (500mg) twice a day (BD).
DIETARY_SUPPLEMENTGroup C (treatment group 2)
In this intervention, participants were instructed to take Syzgium cumini (500mg) twice a day (BD).
COMBINATION_PRODUCTGroup D (treatment group 3)
In this intervention, participants were instructed to take both Withania somnifera and Syzgium cumini (1000 mg) once a day (QD).
Sponsors
Riphah International University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
This was a randomized controlled trial. Participants were divided into four groups. One group was the "control group". They were instructed to take their usual medication for hyperlipidemia. While, participants in the experimental group (B, C and D) were asked to take Withania somnifera and Syzgium cumini separately and in combination.
Intervention model description
This was a randomized controlled trial. Participants were divided into four groups. One group was the "control group". They were instructed to take their usual medication for hyperlipidemia. While, participants in the experimental group (B, C and D) were asked to take Withania somnifera and Syzgium cumini separately and in combination.
Eligibility
Sex/Gender
ALL
Age
25 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Both male and female participants. * Age group 25 - 65 years. * Participants with at least one of the given factors (cholesterol more than 200 mg/dl, LDL more than 130mg/dl, HDL less than 40 mg/dl, triglycerides more than 200 mg/dl, VLDL more than 30mg/dl and non-HDL cholesterol more than 160mg/dl)
Exclusion criteria
* Pregnant and lactating women. * Patients with chronic diseases or illness. * Individuals with any food allergies. * Individuals with congenital abnormalities. * Individuals with psychological disorder. * Individuals with history of moderate to severe intensity of gastrointestinal issues. * Participants of treatment group must not be taking anti-hyperlipidemic medicines.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in Lipid Profile | 3 months | Lipid profile was measured using a RX Daytona+ machine on the fasting for 9-12 hours. The difference between the before and after values was calculated to assess the effectiveness of the individual and combined treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in Body Weight | 3 months | Body weight was measured using both digital and mechanical weight scale. The difference between the before and after values was calculated to assess the effectiveness of the individual and combined treatment. |
| Improvement in Body Mass Index (BMI) | 3 months | Body mass index was calculated by using its standard formula in which weight in kilogram is divided by height in meter per square (weight (kg) / height (m2)). The difference between the before and after values was calculated to assess the effectiveness of the individual and combined treatment. |
| Improvement in Blood Pressure | 3 months | Blood Pressure was measured by a sphygmomanometer. The difference between the before and after values was calculated to assess the effectiveness of the individual and combined treatment. |
Countries
Pakistan
Contacts
STUDY_DIRECTORProf Dr. Muhammad Imran Hussain
Rashid Latif Khan University
Outcome results
None listed