Aplastic Anemia, Autoimmune Hemolytic Anemia, Functional Near-Infrared Spectroscopy, Myelodysplastic Syndromes
Conditions
Brief summary
Anemia is a global public health concern and is closely linked to dysfunction of brain cognitive neural networks, a key mechanism underlying cognitive impairment. Such deficits-including declines in memory, learning, processing speed, and executive function-reduce daily living abilities and increase risks of falls and depression. Functional near-infrared spectroscopy (fNIRS) enables real-time monitoring of oxygenated and deoxygenated hemoglobin fluctuations, reflecting brain network function. This study aims to identify affected neural network regions in anemic patients and visualize connectivity changes using heatmaps and arc-based mapping. The findings will support early detection of cognitive impairment and guide precise clinical interventions, ultimately informing individualized treatment strategies to enhance therapeutic outcomes and quality of life.
Interventions
None listed
Sponsors
Institute of Hematology & Blood Diseases Hospital, China
Tianjin University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of anemia * First hospitalization * Male or female, aged 18-65 years * Willing and able to comply with the requirements for this study and written informed consent
Exclusion criteria
* History of psychiatric illness * History of severe brain disease * Subjects that the investigator believes have other reasons that make them unsuitable for inclusion in this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration changes in oxygenated hemoglobin (HbO) and de-oxygenated hemoglobin (HbR) | Patients will be assessed within 48 hours of admission. | Functional Near Infrared Spectroscopy (fNIRS) is a non-invasive brain imaging modality, that can be used to measure HbO and HbR concentrations. |
| Cognitive Function Assessment | Patients will be assessed within 48 hours of admission. | Montreal Cognitive Assessment (MoCA) is used to assess cognitive function in patients, with higher total scores indicating better cognitive function. The total score range is 0 to 30. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Anxiety symptoms | Patients will be assessed within 48 hours of admission. | Hamilton anxiety scale(HAMA) is used to examine anxiety in AIHA patients, with higher total scores indicate more severe anxiety symptoms. The total score range is 0-56. |
| Depression symptoms | Patients will be assessed within 48 hours of admission. | Hamilton depression scale(HAMD) is used to examine depression in AIHA patients, with higher total scores indicate more severe depression symptoms. The total score range is 0-52. |
| Sleep quality | Patients will be assessed within 48 hours of admission. | The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality, with a higher global score indicating poorer sleep quality. The global score range is 0-21. |
| Physical fatigue | Patients will be assessed within 48 hours of admission. | It measured by the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Scale. The total possible score is 0-52 points, with higher scores indicating less fatigue. |
| Appetite condition | Patients will be assessed within 48 hours of admission. | Simplified Nutritional Appetite Questionnaire (SNAQ) is used to assess appetite in patients, with higher total scores indicating better appetite. The total score range is 4 to 20. |
Countries
China
Contacts
CONTACTZheXiang Kuang, MSN
CONTACTXiao Yu, Undergraduate
Outcome results
None listed