Magnetic Resonance Imaging, Multiparametric, Muscle Invasive Bladder Cancer, Validation, Vesical Imaging Reporting and Data System (VI-RADS)
Conditions
Brief summary
This research aimed to determine how accurately multiparametric magnetic resonance imaging (MRI), when interpreted using the VI-RADS scoring system, can distinguish between invasive and non-invasive bladder cancer.
Detailed description
Bladder cancer (BC) is among the most widespread malignancies needing management. The majority of bladder cancers are urothelial cell carcinomas, which are further classified histologically into low-grade and high-grade categories. Multiparametric magnetic resonance imaging (mpMRI), a recent advancement in MRI technology, combines functional sequences like DWI and DCE-MRI with anatomical T1- and T2-weighted images. This integrated approach enhances tumor detection and staging accuracy, aids in post-therapy response monitoring, and facilitates the identification of local disease recurrence.
Interventions
OTHERMagnetic resonance imaging
All patients underwent magnetic resonance imaging evaluation.
Sponsors
Ain Shams University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Both sexes. * Patients with bladder masses diagnosed through ultrasound, computed tomography, or magnetic resonance imaging (MRI), who were scheduled for cystoscopy.
Exclusion criteria
* Contraindications to MRI (such as metallic prostheses or pacemakers). * Contraindications to Transurethral Resection (like unfitness for anesthesia or urethral strictures). * Elevated serum creatinine levels (precluding IV contrast-enhanced imaging).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity of VI-RADS score for invasion through the bladder wall | 3 months after the procedure | Sensitivity of VI-RADS score for invasion through the bladder wall was recorded. At the end VI-RADS scoring was calculated using all categories, to know the probability of muscle invasion as follows: VI-RADS 1 (very low probability of muscle invasion ): SC, CE, and DW category 1; VI-RADS 2 (low probability of muscle invasion): SC, CE, and DW category 2; both CE and DW category 2 with SC category 3; VI-RADS 3 (muscle invasion is equivocal): SC, CE, and DW category 3; SC category 3 and CE or DW category 3, with the remaining sequence in category 2; (Category 3 should be applied when category 2 findings are absent in their respective sequences but there is no apparent disruption of the typical SI in the muscularis propria, there may be Misclassifications in the VI-RADS 2-3 group). |
Countries
Egypt
Outcome results
None listed