Healthy Aortic Blood Flow
Conditions
Keywords
Blood flow, Aorta, Magnetic Resonance Imaging, PC 4D-flow MRI, MRI
Brief summary
This study aims to gain insights into aortic blood flow in healthy volunteers using PC 4D-flow MRI
Detailed description
The goal of this observational study is to obtain PC 4D flow MRI scans in seventy healthy volunteers (without any known history of cardiovascular disease) to quantify local blood flow in the thoraco-abdominal aorta and its primary side branches and extract boundary conditions for future in-vitro and in-silico studies. Furthermore, the 3D geometry of the vessels within investigated FOVs, starting from ascending aorta to internal/external iliac arteries, will be obtained by performing a separate MRI sequence. Participants will be asked to undergo MRI scans and are asked to fill out a questionnaire regarding their age, weight, height, and gender. By relating this data to the blood flow patterns observed in the aorta, conclusions can be drawn on the differences in blood flow with gender and how aortic blood flow changes with age.
Interventions
OTHER4D-flow Magnetic Resonance Imaging
Subjects will undergo MRI scans of the thorax and abdomen from which we will derive aortic blood flow velocity fields. This intervention will be performed in the same manner on all groups.
OTHERQuestionnaires
Subjects fill in a questionnaire regarding their weight, height, age and gender. They also fill in a safety check form to test if MRI can be applied safely.
Sponsors
University of Twente
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy (in particular without any cardiovascular disease or history thereof) men or women * 18 years of age or above; * BMI ≤ 30; * Willingness to undergo MRI scans; * Able to provide signed informed consent (IC)
Exclusion criteria
* Irregular heartbeat.; * Any history of cardiovascular disease or current cardiovascular disease; * The standard MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Aortic blood flow velocity fields | Day 1 | Velocity fields will be acquired, consisting of vectors that describe the velocity magnitude (cm/s) and direction (dimensionless) of blood flow in the aorta. For visualisation purposes, arrows will be used to overlay the shape of the volunteers aorta. Colours of the arrrows indicate the velocity magnitude and direction of the arrows inicate the direction of flow. Velocity fields are generated for the the full aorta, from the ascending aorta to internal/external iliac arteries, including branched arteries such as subclavian arteries, common carotid artery, and visceral branch vessels. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Turbulent Kinetic Energy | Day 1 | Turbulent Kinetic Energy (J/kg) is a hemodynamic parameter describing the energy related to the fluctuations in blood flow velocity. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle. |
| Helicity | Day 1 | Helicity (m\^4/s\^2) is a hemodynamic parameter that describes how much the blood flow follows a corkscrew-like pattern. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle. |
| Vorticity | Day 1 | Vorticity (s\^-1) is a hemodynamic parameter that reflects the rotational nature of the blood flow. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle. |
| Age of volunteer | Day 1 | Age of volunteer (in years) for division into groups based on gender and age, gathered using a questionnaire. |
| Gender of volunteer | Day 1 | Gender of volunteer (male/female/other) for division into groups based on gender and age, gathered using a questionnaire. |
| Height of volunteer | Day 1 | Height (in m) for BMI (in kg/m\^2) calculation, gathered using a questionnaire. |
| Weight of volunteer | Day 1 | Weight (in kg) for BMI (in kg/m\^2) calculation, gathered using a questionnaire. |
| Aortic blood flow waveforms | Day 1 | Waveforms will be acquired that show how aortic blood flow in a certain region of interest progresses over the cardiac cycle, presented as plots of velocity magnitude (cm/s) over time (s). Regions of interest are selected in the ascending aorta, descending aorta, carotid arteries, subclavian arteries, renal arteries, suprarenal aorta, abdominal aorta, common iliac arteries, internal iliac arteries, and external iliac arteries. |
| Wall shear stress | Day 1 | Wall shear stress (Pa) is a hemodynamic parameter expressing the force acting on a certain area of the vessel wall by the flow of blood. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle. |
| Kinetic Energy | Day 1 | Kinetic Energy (J) in the field of fluid mechanics describes the energy related to the flow of blood in a certain region of interest with a certain mass or volume. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle. |
| Oscillatory Shear Index | Day 1 | Oscillatory Shear Index (dimensionless) is a hemodynamic parameter that defines how much the wall shear stress field changes directions over time, which can tell something about whether the forces on the wall (and the flow of blood) are more uniform or more complex. This parameter will be extracted from the blood flow velocity vectors in a certain region of interest (e.g. in the ascending aorta, descending aorta, renal arteries, or iliac arteries) and will be plotted over the cardiac cycle. |
Countries
Netherlands
Contacts
CONTACTMarleen E. Krommendijk, ir.
PRINCIPAL_INVESTIGATORMichel M.P.J. Reijnen, prof. dr.
University of Twente
Outcome results
None listed