Jaundice
Conditions
Keywords
Grape (VITIS VINIFERA) Seed Powder and Vitamin C
Brief summary
Jaundice is a frequent medical problem that affects people of all ages. It is important to note that jaundice is not an actual sickness as such itself but rather a symptom of liver illness brought on by an increase in the quantity of bilirubin circulating in the blood owing to improper metabolism and excretion in the urine. The aim of this investigation is to investigate the impact of grape (Vitis Vinifera) seed powder along with vitamin C supplementation on serum bilirubin levels in patients with acquired hepatic jaundice. In addition, it's the first research of its kind to investigate the aforementioned function of grape seed extract with vitamin C in healthy individuals specifically.
Detailed description
According to my study, the division of patients was done between two groups: one was named as Conventional group (CG) and other was named as Intervention group (IG). The conventional treatment group received only conventional medication and intervention group was given Grape-C capsule with dose of one tablet per day for 4 weeks after lunch along with conventional medication. Grape-C capsule continued for 4 weeks and the data was obtained at the initiation and at end of intervention (after 4th week). According to my research study results the intervention group had a significant decrease in bilirubin levels, ALT, AST, ALP and increase the albumin and gamma glutamyl transferase (GGT) compared to the conventional group. The p-values for the comparison between pre and post intervention levels were highly significant rather than the conventional groups indicating a statistically significant difference.
Interventions
DIETARY_SUPPLEMENTGrape-C supplement
Grape-C supplement purchased from Nutrifactor brand.
Sponsors
University of Lahore Hospital (ULH)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Both men and women * Participants between the ages of 20-40 years will be included * Patients having signs and symptoms of acquired hepatic jaundice * Patients having high serum bilirubin, albumin, ALT, AST, ALP levels * The patient having ALT level more than 10-50 U/L were included * The participants having AST level above than 0-40 IU/L were included in this study * Patients having ALP level more than 30 - 130 U/L were included in this research study * Patients having level of bilirubin above than 0 - 21 μmol/L were included in this investigation * Participants having the range of albumin more than 30-50 g/L were included in this research * Participants those were underweighted were included
Exclusion criteria
* Patients who already taking any supplement or medication * Participants taking any anti-inflammatory medications * People who were suffering from any other disease * Patients who have any known allergies * Non willing patients * Lactating women * Pregnant women * Smokers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bilirubin levels | 4 weeks | In this study results showed the significant decrease in bilirubin levels in interventional group as compared to the conventional group |
Countries
Pakistan
Contacts
STUDY_CHAIRDr Habib-ur-Rehman Rehman, PhD Food and Nutrition
University of Lahore
Outcome results
None listed